Pyrrolizidine alkaloids from Senecio argunensis

Chemical and Pharmacological Research on Plants from the Genus Senecio

“…S. argunensis is a traditional Chinese medicinal plant, which is widespread in northwestern China and used to treat dysentery, conjunctivitis, and tumefaction. Compounds 30,37,39,44,68, and the new alkaloid (60) were isolated from this plant [17]. Apart from florosenine (72), a new alkaloid was isolated from S. adonidifolius and identified as (12S,15R,20R)-15,20-epoxy-15,20-dihydro-12,13,19-trihydroxysenecionane-11,16-dione (61) [31].…”

Chemical Composition of and Inhibition of Angiotensin-Converting Enzyme bySenecio samnitum huet.

“…The structures of the compounds were determined on the basis of their spectral data (UV, IR, MS, 1 H NMR, and 13 C NMR) and were identical with those previously described (Liu & Roder, 1991).…”

Sesquiterpenoids and Other Constituents from Senecio argunensis

“…1) Mongolian also used it to cure trauma and fracture. Previous phytochemical studies of this plant have led to the isolation of pyrrolizidine alkaloids, 2) flavonoid alkaloids, 3) flavonoid, 4) monoterpene and tetrahydronaphthene derivatives, 5) and cyclohexanone derivatives. 6) As a part of our ongoing study on the finding antibacterial and antifungal sesquiterpenoids from poisonous plants scattered in northeast China, the lesser polar constituents of S. argunensis were systematically investigated.…”

“…6) As a part of our ongoing study on the finding antibacterial and antifungal sesquiterpenoids from poisonous plants scattered in northeast China, the lesser polar constituents of S. argunensis were systematically investigated. As a result, three new sesquiterpenoids, isodauc-7(14)-en-6a,10b-diol (1), 10b-hydroxyisodauc-6-en-14-al (2), and (7S*)-opposit-4(15)-en-1b,7-diol (4), along with nine known compounds, artabotrol (3), 7) (7R*)-opposit-4(15)-en-1b,7-diol (5), 8) opposit-4(15)-en-1b, 11-diol (6), 9) loliolide (7), 10) 5a,6a-epoxy-3b-hydroxymegastigm-7-en-9-one (8), 11) chromolaevane dione (9), 12) pregn-4-en-3,20-dione (10), 13) 12b-hydroxypregn-4-en-3,20-dione (11), 14) ergost-6,22-dien-3b,5a,8a-triol (12), 15) (23Z)-cycloart-23-en-3b,25-diol (13) 16) have been isolated from the aerial parts of this plant. This paper deals with the isolation and structure determination of three new constituents.…”