Pyrrolizidine Alkaloids from <i>Heliotropium megalanthum</i>

Reina, Matı́as; González-Coloma⊥, Azucena; Gutiérrez, Carmen; Cabrera, Raimundo; Henriquez, J.; Villarroel, Luís

doi:10.1021/np980175a

Cited by 28 publications

(18 citation statements)

References 26 publications

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“…Acid dyes and the salt combined into non-ferrous complex, this complex can be extracted by organic solvent (chloroform). This experiment used aconitine as reference material [7][8][9][10]. Total alkaloid content was determined form roots, stems, leaves and fruits of the Actinidia arguta under the condition of NaOH-KHC 8 H 4 O 4 for buffer solution pH = 4 and bromocresol green for chromogenic agent [11].…”

Section: Resultsmentioning

confidence: 99%

Determination of Total Alkaloids in Different Parts of Actinidia arguta by Spectrophotography

Liu¹,

Liu

2015

Advances in Engineering Research

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Abstract. Total Alkaloids are important active materials of Actinidia arguta. However, no study has been conducted to explore the content determination method of the Actinidia arguta total alkaloid. An effective method was established in order to determine the total alkaloids from different parts of Actinidia arguta. Using ultrasonic cleaner, the total alkaloids were extracted from the samples and tested at 415nm with the spectroscopy by the means of acid dye method. The calibration curve of aconitine were linear (r=0.9997), and the recovery rate was prefect (98.9%). The results of measurement were consistent in 3 hours. The content of alkaloids in roots was the highest, with 1.25mg/g, followed by leaves and fruits, the least were stems. The method is simple and effective, and the contents of total alkaloids were different in different parts of Actinidia arguta.

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Section: Resultsmentioning

confidence: 99%

Determination of Total Alkaloids in Different Parts of Actinidia arguta by Spectrophotography

Liu¹,

Liu

2015

Advances in Engineering Research

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“…7,15 The results of an extensive application of 1D ( 1 H NMR, proton broad-band decoupled and DEPT- 13 C resonance assignments of these two pyrrolizidine alkaloids (1 and 2).…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3] These metabolites have been isolated from a wide variety of plants, especially from genera belonging to the Boraginaceae family. [4][5][6] The genus Heliotropium, a well-known source of such alkaloids [7][8][9] and other minor compounds, such as flavonoids and geranyl aromatic derivatives, is constituted of about 250 species represented by herbs and shrubs, distributed throughout the terrestrial globe. 10 In the course of a search for novel and biologically active compounds from plants the EtOH extract from the roots of Heliotropium indicum L., popularly known as fedegoso, found abundantly in the region of northeast Brazil, was investigated.…”

Section: Introductionmentioning

confidence: 99%

Pyrrolizidine alkaloids from Heliotropium indicum

Souza¹,

Machado²,

Pessoa³

et al. 2005

J. Braz. Chem. Soc.

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Um novo alcalóide denominado Helindicina (1), e o conhecido licopsamina (2) foram isolados das raízes de Heliotropium indicum (Boraginaceae). As estruturas foram estabelecidas tendo como base um amplo estudo de 1D e 2D RMN (COSY, HMBC, HMQC, NOESY) e HREIMS. Este representa o primeiro relato de um alcalóide contendo um anel lacônico no gênero Heliotropium. Estes alcalóides mostraram moderada atividade antioxidante.Helindicine (1), a new pyrrolizidine alkaloid with unusual structural features, together with the known lycopsamine (2), were isolated from the roots of Heliotropium indicum (Boraginaceae). The structures were established by a combination of 1D and 2D NMR methods (COSY, HMQC, HMBC, and NOESY) and HREIMS. This is the first report of a lactone pyrrolizidine alkaloid in the genus Heliotropium. Compounds 1 and 2 were assayed for antioxidant activity and showed moderate activity.

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“…Europine 10 isolated from H. bovei showed an SPIC50 of 740 mg/L against F. moniliforme, while 7-acetyleuropine was inactive [129]. It is interesting to see that a related alkaloid, lycopsamine isolated from H. megalanthum was inactive against Fusarium while being active against other phytopathogenic fungi [130]. From the plant Senecio jacobaea, retrorsine and retrorsine-Noxide were isolated and showed to reduce the growth of F. oxysporum but were not able to arrest their development [131].…”

Section: Alkaloidsmentioning

confidence: 99%