Pyrroles and their Benzo Derivatives: Synthesis

Crystal structure of methyl-2-methyl-4-(2-oxo-2-phenylethyl)-5-phenyl-1H-pyrrole-3-carboxylate, C21H19NO3

“…The pyrrole [4][5][6][7] ring is one of the most common skeletal features found in heterocycles and natural products [8][9][10]. Generally, pyrroles possess a broad spectrum of biological activities such as antimicrobial [11], telomerase inhibitory [12], antifungal [13], cardiotonic [14], pheromonal [15], and phytotoxic e ects [16].…”

Solvent-free synthesis of polysubstituted pyrroles catalyzed by ZnO nanorods

“…The pyrrole structural unit is widely used in numerous natural products like heme, chlorophyll, vitamin B 12 , and various cytochrome enzymes, [1] and electrical conducting materials [2]. In addition to this, pyrrole derivatives exhibit remarkable activities such as antitumor [3], anti-HIV [4], anti-inflammatory [5,6], antioxidant [7], antibacterial [8,9], anticandida [10], and antifungal [11].…”

Cobalt(II) chloride as a novel and efficient catalyst for the synthesis of 1,2,5‐trisubstituted pyrroles under solvent‐free conditions

“…Pyrroles are an important class of heterocyclic compounds having different biological activities [1]. Members of this family have wide applications in medicinal chemistry, being used as antimalarial, antiinflammatory agents, antiasthmatic, antibacterial, antihypertensive, and tyrosine kinaseinhibiting agents [2].…”