Pyrrole thioamide complexes of organo-rhodium(III), -iridium(III) and -ruthenium(II)

Influence of counterions on the formation of supramolecular platinum group metal complexes containing pyridyl thioamide derivatives: antioxidant and antimicrobial studies

“…The appearance of a sharp peak of n (P-F) stretching frequency at 841-844 cm À1 suggested the formation of the binuclear complexes. The presence of the n (N3) band at 2047-2030 cm À1 confirmed the formation of di-azido complexes (22)(23)(24)(25)(26)(27)(28)(29)(30). Despite the presence of two N 3 groups, only one sharp band was observed, indicating they were in an identical position.…”

“…The 1 H-NMR of azido complexes (22)(23)(24)(25)(26)(27)(28)(29)(30) shows an unusual splitting in the case of ruthenium complexes where the pyridyl protons split into four doublets with one proton each at around 8.71-7.11 ppm. The aliphatic piperidine, morpholine, and thiomorpholine groups were observed as many multiplets in the range of 4.68-1.56 ppm.…”

“…[((p-Cymene)RuCl) 2 (l-(NS) -L1) 2 ](PF 6 ) 2 (10). Yield: 82%, color: orange; IR (KBr, cm À1 ): 2967 n (C-H) (sp 3 General procedure for the synthesis of di-azido complexes (22)(23)(24)(25)(26)(27)(28)(29)(30) The corresponding starting complexes of 1-9 and an excess of NaN 3 in 1 : 4 molar ratio were suspended in dry methanol (15 ml) and stirred at room temperature for 6 h. The solvent was removed to dryness using a rotary evaporator. The residue was extracted with dichloromethane, filtered, and precipitated with hexane.…”

“…21 Recently, Tang and co-workers have reported the complexes of rhodium( iii ) and iridium( iii ) containing pyrrole thioamide ligands and also investigated their biological activity towards A549 (adenocarcinomic human alveolar basal epithelial) cells. 22 Also, these complexes were known for their reactivity with azide salts forming either azido or diazido complexes which on further reaction with activated alkynes, may yield triazolato complexes. 23 The azido and diazido complexes of platinum group metal complexes are also known for their photoactivated anticancer chemotherapy.…”

Cell Death Mechanism of Organometallic Ruthenium(II) and Iridium(III) Arene Complexes on HepG2 and Vero Cells

“…Ru­(II)–arene complexes with N and P donors have been widely investigated in literature, whereas studies on complexes with S donors are somewhat limited . Henderson et al reported the cytotoxic activities of N,S-coordinated mono- and bimetallic organo-rhodium­(III), -Ir­(III) and -Ru­(II) complexes on A549 cells . Thiolato-bridged, dinuclear, arene–Ru complexes are the most promising biological agents to substitute cisplatin in future cancer therapy strategies .…”