“…In 2010, T. Takayama and co-workers reported the synthesis and characterization of a novel series of 2,3,4,5-tetrasubstituted pyrrole derivatives as lymphocyte-specic kinase (Lck) inhibitors through their enzyme inhibitory activity, cellular activity against mixed lymphocyte reaction (MLR14), and structureactivity relationships (SAR) (Scheme 12). 69 In 2013, C. Mukhopadhyay and his group described a onepot, organocatalyzed, multicomponent synthesis of 3H-pyrrole derivatives from ketones, malononitrile and thiols in ecobenign solvent (Scheme 13). 70 This novel 3H-pyrrole synthesis presented an entirely new approach involving the dual role of the cyano moiety acting both as a carbon center nucleophile and an electrophile.…”