Abstract:Pyroptosis, a newly characterized type of inflammatory programmed cell death (PCD), is usually triggered by multiple inflammasomes which can recognize different danger or damage‐associated molecular patterns (DAMPs), leading to the activation of caspase‐1 and the cleavage of gasdermin D (GSDMD). Gasdermin family pore‐forming proteins are the executers of pyroptosis and are normally maintained in an inactive state through auto‐inhibition. Upon caspases mediated cleavage of gasdermins, the pro‐pyroptotic N‐termi… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.