Pyroptosis and its therapeutic potential

Abstract

The review examines present data on pyroptosis – a type of programmed cell death associated with infection with various pathogens. During pyroptosis. specific molecular complexes, inflammasomes, are formed, caspases are activated, and proinflammatory cytokines are produced. We consider the mechanisms of pyroptosis activation, including canonical and non-canonical pathways, as well as methods for its detection in cells. The review substantiates the relevance of studying the role of pyroptosis in pathological processes in different tissues. We focus on the therapeutic potential of pyroptosis, including its role in the treatment of sepsis. Pyroptosis is involved in sepsis-induced tissue damage in various organs, so regulation of this type of cell death can serve as the basis for the development of innovative treatment methods.