Pyroptosis and its relationship to atherosclerosis

Xu, Yuzhong; Zheng, Lei; Hu, Yan‐Wei; Wang, Qian

doi:10.1016/j.cca.2017.11.005

Cited by 246 publications

(205 citation statements)

References 119 publications

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“…This enzyme is involved in hydrolyzing extracellular ATP into ADP which can be further converted into the immunomodulatory adenosine by ecto-5′nucleotidases such as CD73 [24]. ATP is a known danger-associated molecular pattern which stimulates pro-inflammatory cytokine production and has been linked to atherosclerosis [25]. We demonstrated an increased expression of CD39 on aortic CD8 + T-cells compared to their splenic counterparts, suggesting a CD39-mediated reduction in cytokine production by lesion-derived CD8 + T-cells.…”

Section: Discussionmentioning

confidence: 99%

CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions

et al. 2019

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• CD8 + T-cells in atherosclerotic lesions show impaired IFN-γ and TNF-α production, associated with expression of CD39. • TCR signaling is required for the upregulation of CD39 + on lesional CD8 + T-cells. • Pharmacological inhibition of CD39 partly restores cytokine production of CD8 + T-cells in the atherosclerotic lesions. • CD8 + T-cells from human lesions display increased expression of CD39 compared to their circulating counterparts.

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Section: Discussionmentioning

confidence: 99%

CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions

et al. 2019

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“…As with apoptosis, the pyroptosis TUNEL assay is also positive. Pyroptosis can also be observed by electron microscopy, lactate dehydrogenase (LDH) release and Hoechst 33342/PI double‐staining, etc …”

Section: Overview Of Pyroptosismentioning

confidence: 99%

“…CD can be observed in As and plays a vital role in the development and progression of As lesions. Pyroptosis is involved in the formation and progression of As by promoting the release of inflammatory factors and is closely related to the stability of the plaque …”

Section: Pyroptosis In Cardiovascular Diseasementioning

confidence: 99%

Role of pyroptosis in cardiovascular disease

et al. 2018

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Cardiac function is determined by the dynamic equilibrium of various cell types and the extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially atherosclerosis and myocardial infarction, are often accompanied by cell death and acute/chronic inflammatory reactions. Caspase-dependent pyroptosis is characterized by the activation of pathways leading to the activation of NOD-like receptors, especially the NLRP3 inflammasome and its downstream effector inflammatory factors interleukin (IL)-1β and IL-18. Many studies in the past decade have investigated the role of pyroptosis in CVDs. The findings of these studies have led to the development of therapeutic approaches based on the regulation of pyroptosis, and some of these approaches are in clinical trials. This review summarizes the molecular mechanisms, regulation and cellular effects of pyroptosis briefly and then discusses the current pyroptosis studies in CVD research.

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“…The morphological changes include necrosis-like cell membrane rupture, pore formation, cellular swelling, proinflammatory intracellular content release, as well as apoptosis-like nuclear condensation and DNA fragmentation. In contrast to apoptosis, pyroptotic cells have an integral mitochondrion and ''balloonshaped'' vesicle formation, but no cytochrome c release (Xu et al, 2018;Jia et al, 2019). Molecularly, pyroptosis is characteristic in gasdermin-mediated cell death (Shi et al, 2017).…”

Section: The Mechanism Of Pyroptosismentioning

confidence: 99%

“…Then, the activated caspase 1 cleaves the gasdermin D (GSDMD) and triggers oligomerization of the GSDMD-N domain in the cell, which finally forms the pores and releases cellular contents, such as IL-1α and HMGB1. Besides, the active caspase 1 is also responsible for processing and maturing IL-1β/18, which cause inflammation (Dinarello, 2011;Xu et al, 2018).…”

Section: The Mechanism Of Pyroptosismentioning

confidence: 99%

Programmed Cell Deaths and Potential Crosstalk With Blood–Brain Barrier Dysfunction After Hemorrhagic Stroke

Fang

Gao

Wang

et al. 2020

Front. Cell. Neurosci.

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Hemorrhagic stroke is a life-threatening neurological disease characterized by high mortality and morbidity. Various pathophysiological responses are initiated after blood enters the interstitial space of the brain, compressing the brain tissue and thus causing cell death. Recently, three new programmed cell deaths (PCDs), necroptosis, pyroptosis, and ferroptosis, were also found to be important contributors in the pathophysiology of hemorrhagic stroke. Additionally, blood-brain barrier (BBB) dysfunction plays a crucial role in the pathophysiology of hemorrhagic stroke. The primary insult following BBB dysfunction may disrupt the tight junctions (TJs), transporters, transcytosis, and leukocyte adhesion molecule expression, which may lead to brain edema, ionic homeostasis disruption, altered signaling, and immune infiltration, consequently causing neuronal cell death. This review article summarizes recent advances in our knowledge of the mechanisms regarding these new PCDs and reviews their contributions in hemorrhagic stroke and potential crosstalk in BBB dysfunction. Numerous studies revealed that necroptosis, pyroptosis, and ferroptosis participate in cell death after subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH). Endothelial dysfunction caused by these three PCDs may be the critical factor during BBB damage. Also, several signaling pathways were involved in PCDs and BBB dysfunction. These new PCDs (necroptosis, pyroptosis, ferroptosis), as well as BBB dysfunction, each play a critical role after hemorrhagic stroke. A better understanding of the interrelationship among them might provide us with better therapeutic targets for the treatment of hemorrhagic stroke.

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Pyroptosis and its relationship to atherosclerosis

Cited by 246 publications

References 119 publications

CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions

CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions

Role of pyroptosis in cardiovascular disease

Programmed Cell Deaths and Potential Crosstalk With Blood–Brain Barrier Dysfunction After Hemorrhagic Stroke

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