Pyrimidine–pyrimidine base pairs stabilized by silver(i) ions

Abstract

In the presence of Ag(I) ions, the C-T and m(5)iC (5-methylisocytosine)-T base pairs showed comparable stability to the C-Ag(I)-C base pair, and the m(5)iC-C base pair was highly stabilized by the synergetic effect of Ag(I) coordination and possible hydrogen bonding.

Covalent linking DNA to graphene oxide and its comparison with physisorbed probes for Hg2+ detection

“…With 1 µM metal ions, Hg 2+ yielded the highest response among all the divalent metal ions ( Figure 5A). Interestingly, Ag + also produced a significant response, and this is attributed to the relatively high affinity between Ag + and pyrimidine bases (Urata et al 2011). A similar response was observed with the non-covalent sensor ( Figure 5B Figure S1 (Supplementary data).…”

A Silver DNAzyme

“…31,32 This interaction was used to develop Ag + biosensors, [33][34][35] ThermoPol buffer and low molecular weight DNA ladder were from New England Biolabs.…”

Communication: UV photoionization of cytosine catalyzed by Ag+

“…Very recently, it has been reported that Ag + can induce the formation of non-canonical DNA pairs such as silver mediated cytosine pair (Cyt 2 Ag + ). 27,28,30 Whereas the excited state lifetime of Cyt is short, 31,32 which is identified as one of the photoprotection mechanisms of DNA, [7][8][9]11,12,33 it was also shown that the lifetime of the Cyt 2 Ag + complex is long, 34 which means that the effect of this cation on the electronic properties of the DNA bases could be very important. We report here the UV photofragmentation spectrum of the gas phase Cytosine-Ag + (CytAg + ) complex as a reductionist approach to gain information about the effect of Ag + on the optical properties of the DNA bases and especially on the mutagenic role of this cation.…”

“…In addition, highly fluorescent silver nanoparticles can be synthesized in cytosine (Cyt) and/or guanine rich DNA templates [23][24][25][26] due to the high affinity and site specificity of Ag + upon interaction with these two bases. 27,28 The fast development of nanoscience and nanotechnology and the fact that silver nanoparticles can be easily synthesized have spread their use in many technological applications in which medicine and biology are not the exception. 29 Despite of the extensive use of Ag + /Ag in medicine and its established strong affinity by DNA, 27,28 insufficient information is available about the secondary effects of the long and short term exposure to this element on the human health.…”

“…27,28 The fast development of nanoscience and nanotechnology and the fact that silver nanoparticles can be easily synthesized have spread their use in many technological applications in which medicine and biology are not the exception. 29 Despite of the extensive use of Ag + /Ag in medicine and its established strong affinity by DNA, 27,28 insufficient information is available about the secondary effects of the long and short term exposure to this element on the human health.…”