Pyrimidine derivatives and related compounds. 4. A route for the synthesis of pyrazolo [3,4-e]-as-triazines, pyrazolo[3,4-d]pyrimidines, and pyrazolo[1,5-c]-as-triazines

Behaviour of Some Activated Nitriles Toward Barbituric Acid, Thiobarbituric Acid and 3-Methyl-1-Phenylpyrazol-5-one

“…A possible pathway for the formation of the arylidene derivatives may be as represented in Scheme 2. The diverse biological activities of fused pyrazoles have stimulated considerable research in this field [6][7][8][9][10][11]. It has been reported [12] that the pyrazolone derivative 5 reacted with α-cyanocinnamonitrile in the presence of piperidine to yield the 1:1 adduct 6.…”

Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1‐c][1,2,4]‐triazines and Pyrazolo[5,1‐c][1,2,4]triazines as Potential Antidiabetic Agents

“…Cyclization of 10a , b proceeds smoothly in refluxing pyridine to give 3‐cyanopyrazolotriazines 11a , b (Scheme ). Pyrazolotriazines with similar structure are described in works .…”

Synthesis and reactivity of cyanomethyl 2-amino-4-methylthiazolyl ketone. A facile synthesis of novel pyrazolo[5,1-c]1,2,4-triazine, 1,2,4-triazolo[5,1-c]1,2,4-triazine, 1,2,4-triazino[4,3-a]benzimidazole, pyridazine-6-imine and 6-oxopyridazinone derivatives

“…Microanalyses were carried out at the Microanalytical Center, University of Cairo, Giza, Egypt. 3-Chloroacetylacetone 2 [10] and heterocyclic diazonium salts 6a,b [11], 10 [12] were prepared according to literature procedures. (3) To a stirred solution of thiourea (1) (15.2 g, 0.2 mol) in absolute ethanol (75 mL) containing a catalytic amount of triethylamine was added dropwise a solution of 3-chloroacetylacetone (26.9 g, 0.2 mol) in 10 mL of absolute ethanol.…”