Pyrimidifen intoxication

Eisinger, Miruna; Almog, Yaniv

doi:10.1067/mem.2003.260

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…It exhibits efficacy against all life stages of spider mites and is also capable of managing the population of diamondback moths (Plutella xylostella L.). Pyrimidifen operates through the same mechanism of action as other pyrimidine acaricides: inhibiting the electron transfer on complex I [67,68] (Figure 15).…”

Section: Insecticides/acaricides Containing a Long Chainmentioning

confidence: 99%

Long-Chain Molecules with Agro-Bioactivities and Their Applications

Yin

Qin

2023

Molecules

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Long-chain molecules play a vital role in agricultural production and find extensive use as fungicides, insecticides, acaricides, herbicides, and plant growth regulators. This review article specifically addresses the agricultural biological activities and applications of long-chain molecules. The utilization of long-chain molecules in the development of pesticides is an appealing avenue for designing novel pesticide compounds. By offering valuable insights, this article serves as a useful reference for the design of new long-chain molecules for pesticide applications.

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Section: Insecticides/acaricides Containing a Long Chainmentioning

confidence: 99%

Long-Chain Molecules with Agro-Bioactivities and Their Applications

Yin

Qin

2023

Molecules

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“…Since the commercialization of diazinon, the first organophosphorus insecticide with a pyrimidine structure developed by Gegi in 1952, pyrimidines have become the focus of novel pesticide development. 7,9 Although pyrimidine amines have a wide range of biological activities and unique modes of action, due to the development difficulties caused by their toxicity and environmental toxicological characteristics, 10,11 few are commercialized (Figure 1).…”

Section: ■ Introductionmentioning

confidence: 99%

Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound

Wang

Wei

et al. 2021

J. Agric. Food Chem.

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Target identification is one of the most important bases for novel pesticide development; pyruvate kinase (PK) was discovered as a potent fungicide target in our previous studies. To continue the PK-based fungicide development, novel isothiazolepurine derivatives were rationally designed and synthesized. Bioassay results showed that compound 5ai displayed excellent in vitro activity against Rhizoctonia solani with an EC 50 of 1.5 μg/mL, which was superior to those of positive controls diflumetorim with its EC 50 of 19.8 μg/mL and PK-based lead YZK-C22 with its EC 50 of 4.2 μg/mL. Compounds 3b (5.2 μg/mL) and 3c (4.5 μg/mL) displayed better activities against Gibberella zeae with their EC 50 s falling between 4.0 and 5.5 μg/mL, while YZK-C22 showed an EC 50 of 6.4 μg/mL. In addition, 5ah exhibited promising in vivo activity against Erysiphe graminis and Puccinia sorghi Schw. with 100% efficacy at 10 μg/mL and 90% efficacy at 2 μg/mL against P. sorghi Schw. Compound 5ai showed good PK inhibitory activity with an IC 50 of 38.8 μmol/L, and it was well docked into the active site of the target enzyme PK, which was slightly more active than YZK-C22 with its IC 50 of 42.4 μmol/L. Our studies discovered that isothiazole-purines were PK-based fungicidal leads deserving of further study.

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“…ATP, produced in the mitochondrial inner membrane, is the common energy source for living organisms, including arthropods. Several commercial insecticidal and acaricidal compounds inhibit electron transport system complex I, including fenpyroximate, 1 fenazaquin 2 and pyrimidifen, 3 and against complex III, such as strobilurin A 4 originating from a fungus. They have proved to be safe for mammals by their selective activity against arthropods.…”

Section: Introductionmentioning

confidence: 99%

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

et al. 2017

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A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.

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Pyrimidifen intoxication

Cited by 5 publications

References 3 publications

Long-Chain Molecules with Agro-Bioactivities and Their Applications

Long-Chain Molecules with Agro-Bioactivities and Their Applications

Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

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