Pyridylphosphinate metal complexes: synthesis, structural characterisation and biological activity

Abstract

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Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes

“…The pKa of compound 1 could not be calculated, as the absorbance bands for the aqua-and the hydroxo-compounds overlap; however, changes could only be observed at pH values higher than 10. These pKa values are high, although such a decrease in acidity has been previously reported (generally attributed to an increased electron density on the metal centre) [60,63,64]. As a consequence of such high pKa, only the aqua adduct of the metal complexes is expected to be present at physiological pH (7.4), thus favouring the reaction between the metal complexes with possible ligands such as nucleobases or proteins.…”

Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria

“…These p K a values are high, although such decrease in acidity has been previously reported (generally attributed to an increased electron density on the metal centre). ( Liu and Sadler, 2014 , Peacock et al., 2006 , Cross et al., 2016 ) As a consequence of such high p K a values, only the aqua adduct of the metal complexes is expected to be present at physiological pH (7.4), thus favouring the reaction between the metal complexes with possible ligands such as nucleobases or proteins.…”

Ruthenium(ii) p-cymene complexes of a benzimidazole-based ligand capable of VEGFR2 inhibition: hydrolysis, reactivity and cytotoxicity studies

“…It is worth mentioning here that halide exchange in all Ru(II) complexes does not necessarily follow a common trend. 38,56 In contrast to the NMR data, upon injecting an aliquot of the NMR sample, after necessary dilution with methanol, no m/z peak was observed in the ESI-MS for the halide-exchanged species in 2 and 3. Only the dehalogenated species [(η 6 -pcymene)Ru II Table S5.…”