Pyridylethylated Benzoxazinediones<sup>1</sup>

Shapiro, Seymour L.; Rose, Ira M.; Freedman, Louis

doi:10.1021/ja01568a039

Cited by 24 publications

(8 citation statements)

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“…Methyl salicylate (3.3 mmol) and 3,4-dimethoxyphenethylamine (6.6 mmol) were mixed at room temperature under magnetic stirring for 6 hours to give 2-hydroxy-N-[2-(4-methoxyphenyl)ethyl]-benzamide (Rip-B, 34% yield). Melting point: 96 °C [23]. 1H and 13C-NMR date: see Table 1 and Table 2.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

et al. 2014

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This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.

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Section: Methodsmentioning

confidence: 99%

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

et al. 2014

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“…]ethyl-6-acyl-2-benzoxazolinones [22,23] To 0.1 mol 6-acyl-2-benzoxazolinone derivatives were added 8 ml 2-and/or 4-vinylpyridine and the reaction mixture heated under reflux in an oil bath until molten and then for 2 additional hours at 150°C. On cooling, the products were poured into crushed ice, and the solid mass which separated out was filtered, dried, and crystallized from ethanol.…”

Section: -[2-(2-/4-pyridyl)mentioning

confidence: 99%

Synthesis of Some New Pyridyl-ethylated Benzoxazolinones with Analgesic and Anti-inflammatory Activities

Palaska¹,

Gökhan²,

Erdoğan³

et al. 2011

Arzneimittelforschung

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Twelve new 3-[2-(2- and/or 4-pyridyl)ethyl]benzoxazolinone derivatives have been synthesized by reacting 2- and/or 4-vinylpyridine and appropriate benzoxazolinones. Their chemical structures have been proven by IR, 1H-NMR and elemental analysis. Analgesic activities of these compounds were investigated by a modified Koster and constant temperature hot-plate test. Test results revealed that most of the compounds at 100 mg/kg dose level showed significant analgesic activities when compared to acetylsalicylic acid and morphine. Therefore the compounds were screened for their anti-inflammatory activities using the carrageenan hind paw edema test. Compounds 3-8 were found more active than indometacin. In gastric ulceration studies, any of the compounds showed no gastrointestinal bleeding at 100 mg/kg dose level.

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“…On adding cold alcohol-water mixture, the product separated, the resulting precipitate was collected by filtration. The crude product was recrystallized from different solvents [22] .…”

Section: -[2-(2-/4-pyridyl)]ethyl-6-acyl-2-benzoxazolinone and 3-[2-mentioning

confidence: 99%

Novel Antiinflammatory Analgesics: 3-(2-/4-Pyridylethyl)-Benzoxazolinone and Oxazolo[4,5-β]pyridin-2-one Derivatives

Gökhan

Erdoğan

Durlu

et al. 1999

Arch. Pharm. Pharm. Med. Chem.

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Twenty‐two new 3‐[2‐(2‐and/or 4‐pyridyl)ethyl]benzoxazolinone and oxazolo[4,5‐b]pyridin‐2‐one derivatives have been synthesized by reacting 2‐and/or 4‐vinylpyridine and appropriate benzoxazolinones and oxazolo[4,5‐b]pyridine‐2‐one. Their chemical structures have been proven by IR, 1H‐NMR, 13C‐NMR, mass spectroscopy, and elemental analysis. The analgesic activities of these compounds were investigated by a modified Koster′s Test. Test results revealed that, at 100 mg/kg dose level, most of the compounds showed significant analgesic activities when compared to aspirin. Therefore the compounds were screened for their antiinflammatory activities using the carrageenan hind paw edema test. Compounds 1, 7, 10, 11, 12, 13, 15, 18, 20, 21 were found more active than indomethacine. In gastric ulceration studies gastrointestinal bleeding was not observed at 100 mg/kg dose level in compounds 1 and 2.

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Pyridylethylated Benzoxazinediones¹

Cited by 24 publications

References 0 publications

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

Synthesis of Some New Pyridyl-ethylated Benzoxazolinones with Analgesic and Anti-inflammatory Activities

Novel Antiinflammatory Analgesics: 3-(2-/4-Pyridylethyl)-Benzoxazolinone and Oxazolo[4,5-β]pyridin-2-one Derivatives

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Pyridylethylated Benzoxazinediones1

Cited by 24 publications

References 0 publications

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

Synthesis of Some New Pyridyl-ethylated Benzoxazolinones with Analgesic and Anti-inflammatory Activities

Novel Antiinflammatory Analgesics: 3-(2-/4-Pyridylethyl)-Benzoxazolinone and Oxazolo[4,5-β]pyridin-2-one Derivatives

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Pyridylethylated Benzoxazinediones¹