Pyridyl unit in host compounds

RuIII Complexes of Edta and Dtpa Polyaminocarboxylate Analogues and Their Use as Nitric Oxide Scavengers

“…All solvents (anhydrous grade) were obtained from Aldrich and used as supplied. K 2 [RuCl 5 (OH 2 )], [50] ({3-[bis(carboxymethyl)amino]propyl}(carboxymethyl)amino)acetic acid (3), [41] N,NЈ-bis(2-pyridylmethyl)-ethylenediamine-N,NЈ-diacetic acid (15), [43] methyl 6-(hydroxymethyl)pyridine-2-carboxylate (17), [44] 6-(hydroxymethyl)pyridine-2-carbaldehyde (21), [45] iminodiacetic acid di-tert-butyl ester, [46] 2,6-bis(bromomethyl)pyridine hydrogen bromide (25), [48] and N-(hydroxyethyl)iminodiacetic acid di-tert-butyl ester [49] were pre-pared according to literature procedures. 1 H NMR and 13 C NMR spectra were recorded with a Bruker Avance 300 with chemical shifts referenced to SiMe 4 .…”

“…Incorporation of a pyridyl moiety into the dtpa framework was realized with the synthesis of compound 26 (Scheme 6). Reaction of two equivalents of iminodiacetic acid dimethyl ester with 2,6-bis(bromomethyl)pyridine hydrogen bromide [48] 25 under basic conditions afforded the deprotected ligand 26 in one step in 71 % yield. Due to the basic nature of the reaction mixture the compound was isolated as the tri-sodium salt.…”

“…The crude material was purified by column chromatography (CH 2 (26). An aqueous solution of sodium hydroxide (30 mL, 10 mm), 2,6-bis(bromomethyl)pyridine hydrogen bromide (25) [48] (1.0 g, 2.9 mmol), iminodiacetic acid dimethyl ester (0.934 g, 5.8 mmol), and cetyltrimethylammonium bromide (0.21 g, 0.58 mmol) was stirred at room temperature for 3 days. A white precipitate formed which was removed by filtration and the filtrate was evaporated to give a white solid.…”

A Thermodynamic and Structural Study of the Interactions of Pyridino- and Diketopyridino-18-Crown-6 Ligands with some Primary Organic Ammonium Cations

“…Macrocycle P18C6 was prepared as reported [8]. Macrocycle K 2 PI8C6 was recrystallized from the product of Parish Chemical Company (Oreni, UT).…”

Piridin egységet tartalmazó királis koronaéterek néhány alkalmazása

“…Az elsõ olyan koronaétert, amely piridin egységet tartalmaz Cram és munkatársai állították elõ 1974-ben, 6 majd késõbb ugyanez a kutatócsoport közölte elõször, hogy a piridin egységet tartalmazó 18-korona-6-éter típusú makrociklusok piridinjének nitrogénatomja erõsebb hidrogénkötést létesít a vizsgált ammónium kationokkal, mint az éteres oxigén atom. 7,8 A piridino-18-korona-6-éterek üregmérete leginkább a K + ionok, illetve a hasonló méretû NH 4 + ionok, így a protonált primer aminok komplexálását is lehetõvé teszi.…”