Pyridoxine treatment in a subgroup of children with pervasive developmental disorders

Kuriyama, Shinichi; Kamiyama, Machiko; Watanabe, M; Tamahashi, Seiko; Muraguchi, Itaru; Watanabe, Tôru; Hozawa, Atsushi; Nishino, Yoshikazu; Tsubono, Yoshitaka; Tsuji, Ichiro; Hisamichi, Shigeru

doi:10.1017/s0012162201232071

Cited by 23 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). Approximately 8% of the U.S. population is deficient in vitamin B 6 ; some preliminary evidence suggests that vitamin B 6 may also promote moderate improvements in some behaviors (90,222,223). Low iron is also common in 16% of menstruating women and 29% of low-income women; iron supplementation has also been shown to help improve some behaviors (224).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

Patrick¹,

Ames²

2015

FASEB j.

387

225

View full text Add to dashboard Cite

Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize previous findings that serotonin regulates executive function, sensory gating, and social behavior and that attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior all share in common defects in these functions. It has remained unclear why supplementation with omega-3 fatty acids and vitamin D improve cognitive function and behavior in these brain disorders. Here, we propose mechanisms by which serotonin synthesis, release, and function in the brain are modulated by vitamin D and the 2 marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Brain serotonin is synthesized from tryptophan by tryptophan hydroxylase 2, which is transcriptionally activated by vitamin D hormone. Inadequate levels of vitamin D (∼70% of the population) and omega-3 fatty acids are common, suggesting that brain serotonin synthesis is not optimal. We propose mechanisms by which EPA increases serotonin release from presynaptic neurons by reducing E2 series prostaglandins and DHA influences serotonin receptor action by increasing cell membrane fluidity in postsynaptic neurons. We propose a model whereby insufficient levels of vitamin D, EPA, or DHA, in combination with genetic factors and at key periods during development, would lead to dysfunctional serotonin activation and function and may be one underlying mechanism that contributes to neuropsychiatric disorders and depression. This model suggests that optimizing vitamin D and marine omega-3 fatty acid intake may help prevent and modulate the severity of brain dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

Patrick¹,

Ames²

2015

FASEB j.

387

225

View full text Add to dashboard Cite

show abstract

“…For example, though there have been several randomized, double-blind crossover studies of melatonin in the ASD population, the sample sizes range from 5–20 children (Garstang & Wallis, 2006; Wasdell et al, 2008; Wirojanan et al, 2009). Similarly, one study reported gains in verbal IQ for children receiving a vitamin B-magnesium combination compared to those in the placebo group; however, there were only four participants in each group (Kuriyama et al, 2002). Other studies that have examined the efficacy of essential fatty acids have also had small sample sizes and have reported no statistically significant reduction in symptomatology in the treatment verses control groups (Bent et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with Autism Spectrum Disorders

Owen-Smith

Bent

Lynch

et al. 2015

Research in Autism Spectrum Disorders

View full text Add to dashboard Cite

Purpose The purpose of the present study was to examine the prevalence and predictors of complementary and alternative medicine (CAM) use as well as parental perceptions of CAM efficacy in a large, geographically diverse sample of children with Autism Spectrum Disorders (ASD). Methodology Data were obtained from a web-based survey administered to parents of children with ASD at four sites participating in the Mental Health Research Network (MHRN). The web survey obtained information about services and treatments received by children with ASD as well as the caregivers’ experiences with having a child with ASD. Results Approximately 88% of the sample had either used CAM in the past or had recently used some type of CAM. The following characteristics were associated with CAM use: greater parental education, younger child age, a mix of regular and special classroom settings and prescription drug use in the past three months. Conclusions The use of CAM was very prevalent in this large, geographically diverse sample of children with ASD. It is critical that providers be prepared to discuss the advantages and potential side effects with families to help them make well-informed health care decisions and prevent possible CAM-drug interactions.

show abstract

“…We conducted cluster analyses using phenotypic variables of ADI-R (17) scores and history of vitamin treatment (18,19). We chose these variables because the ADI-R is one of the most reliable estimates of ASD and has the ability to evaluate substructure domains of ASD (17).…”

Section: Clusteringmentioning

confidence: 99%

“…The SSC data were publicly released in October 2007 and are directly available from the SFARI. From the SSC dataset, we used data from 614 affected white male probands who had no missing information regarding Autism Diagnostic Interview-Revised (ADI-R) scores (17) and vitamin treatment (18,19) and 391 unaffected brothers for whom genotype data, generated by the Illumina Human Omni2.5 (Omni2.5) array, were available for subsequent clustering and genetic analyses. We excluded participants whose ancestries were estimated to be different from the other participants using principal component analyses (PCAs) performed by EIGENSOFT version 7.2.1 (20, 21) for the genotype data.…”

mentioning

confidence: 99%

Clustering by phenotype and genome-wide association study in autism

Narita

Nagai

Mizuno

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have more power to elucidate hidden heritability. Methods:We conducted cluster analyses using the k-means algorithm with a cluster number of 15 based on phenotypic variables from the Simons Simplex Collection (SSC). As a preliminary study, we conducted a conventional genome-wide association study (GWAS) with a dataset of 597 ASD cases and 370 controls. In the second step, we divided cases based on the clustering results and conducted GWAS in each of the subgroups vs controls (cluster-based GWAS). We also conducted cluster-based GWAS on another SSC dataset of 712 probands and 354 controls in the replication stage. Results:In the preliminary study, we observed no significant associations. In the second step of cluster-based GWASs, we identified 65 chromosomal loci, which included 30 intragenic loci located in 21 genes and 35 intergenic loci that satisfied the threshold of P<5.0×10 −8 . Some of these loci were located within or near previously reported candidate genes for ASD: CDH5, CNTN5, CNTNAP5, DNAH17, DPP10, DSCAM, FOXK1, GABBR2, GRIN2A5, ITPR1, NTM, SDK1, SNCA and SRRM4. Of these 65 significant chromosomal loci, rs11064685 located within the SRRM4 gene had a significantly different distribution in the cases vs. controls in the replication cohort. Conclusions:These findings suggest that clustering may successfully identify subgroups with relatively homogeneous disease etiologies. Further cluster validation and replication studies are warranted in larger cohorts.

show abstract

Pyridoxine treatment in a subgroup of children with pervasive developmental disorders

Cited by 23 publications

References 9 publications

Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with Autism Spectrum Disorders

Clustering by phenotype and genome-wide association study in autism

Contact Info

Product

Resources

About