Pyridoxine in clinical toxicology: a review

Lheureux, Philippe; Penaloza, Andréa; Gris, Mireille

doi:10.1097/00063110-200504000-00007

Cited by 125 publications

(77 citation statements)

References 41 publications

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“…8,9 There have also been several reports of liver toxicity with prolonged highdosage use of PLP, 10, 11 but overall pyridoxine and PLP supplementation are generally well tolerated. 7,8,10,12 To our knowledge, no bleeding symptoms have been reported in those taking either pyridoxine or PLP.…”

Section: Discussionmentioning

confidence: 78%

“…PLP is required for the function of many essential enzymes in amino acid metabolism, neurotransmitter synthesis, and glycogen catabolism. 5,7,12 Control of seizures in PNPO deficiency often requires lifelong supplementation with high doses of PLP, although some patients may also respond to pyridoxine therapy. 17 Hemophilia A is a rare X-linked recessive bleeding disorder characterized by reduced presence and activity of coagulation factor VIII.…”

Section: Discussionmentioning

confidence: 99%

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B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity

Borst

Tchapyjnikov

2018

Pediatrics

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Pyridox(am)ine-5-phosphate oxidase deficiency is an inborn error of vitamin B6 metabolism that is characterized by neonatal seizures, requiring lifelong therapy with pyridoxal-5-phosphate. We present the first case of a patient with pyridox(am)ine-5-phosphate oxidase deficiency and mild hemophilia A, whose bleeding symptoms were exacerbated by the vitamin B6 therapy essential for his epileptic disorder. This report expands the spectrum of known vitamin B6 toxicity and demonstrates a need for vigilance in monitoring for bleeding symptoms in patients requiring pyridoxine or pyridoxal-5-phosphate supplementation.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity

Borst

Tchapyjnikov

2018

Pediatrics

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“…What remains clear is that combination, multimodality therapy is required for the effective treatment of NAFLD. According to the beneficial effect of metadoxine, as an antioxidant, it could be recommended as a supplementary drug within this treatment [35,61].…”

Section: Dietary Causesmentioning

confidence: 99%

The beneficial effect of metadoxine (pyridoxine-pyrrolidone-carboxylate) in the treatment of fatty liver diseases

Fehér¹,

Váli²,

Blázovics³

et al. 2009

Clinical and Experimental Medical Journal

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Hepatic steatosis involves an imbalance between the processes of the hepatocytes' lipid uptake and lipid elimination, an overproduction results in the accumulation of excess triglycerides in the cells of the liver. Normally about 5% of the cells contain triglyceride; in steatosis this may exceed 50%. Under 50% the condition is called fatty infiltration, and over 50% it is called fatty liver. In mild forms this does not necessarily lead to disorders in cell functions, but in more severe forms it does; it often precedes the death of the cell. Fatty liver can be considered a pathologic condition which makes the liver more susceptible to other toxic influences. It is not a genuine disease; in most cases it is associated with a noxious state or other pathologic process. Alcohol-induced fatty liver is a current epidemie. The abnormal accumulation of fat in parenchymal organs, including the liver, is called fatty transformation or steatosis. Alone and limited to a certain degree of severity (the appearance of fibrosis), it represents a reversible damage; upon cessation of the underlying cause the liver clears its excess triglyceride content. The treatment is to be aimed at the underlying process; up to now there is no known specific medicine that could clearly reduce the fat accumulated in the hepatocytes. Although the etiologic factors of these diseases differ from each other, the pathological changes in the liver are very similar, thus certain drugs could be equally effective for treating them both. Metadoxine is one of those drugs, mainly due to its liver-protective effect against damage from free radicals. As an effective antioxidant, metadoxine regulates glutathione levels in the liver and throughout the body, thus positively influencing the maintenance of systemic redox homeostasis. The authors discuss in detail the effect of metadoxine in the treatment of fatty liver diseases (alcoholic and non-alcoholic), they also review the effect of metadoxine in both in vitro and in vivo experimental conditions.

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“…zoniazid, ucuz ve etkin olmas nedeniyle 1952'den beri tüberküloz tedavisi ve korunmas nda yayg n olarak kullan lan birinci grup ilaçlardan biridir. [1] Artan tüberküloz s kl ile uyumlu olarak son y llarda acil polikliniklerinde akut izoniazid zehirlenmesiyle gelen olgularda art gözlenmektedir. zoniazid (INH), yüksek dozlarda al nd nda dozla ili kili olarak konvülsiyon, metabolik asidoz, laktik asidoz, rabdomiyoliz, koma ve hatta uygun tedavi edilmedi i takdirde ölümle sonuçla-nabilir.…”

Section: G Runclassified

“…Tedavinin en önemli ad m al nan izoniazide e dozda parenteral piridoksin verilmesidir. [1][2][3] Bu yaz da konvülsiyon geçirdi i için getirilen s ras yla 3,5 ya , 4,5 ya ve 4 ya nda üç olgu sunulmaktad r.…”

Section: G Runclassified

Isoniazid Overdose: Three Cases Reports

Dede¹,

Yılmaz²,

Yıldızdaş³

et al. 2009

TUTFD

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© Trakya Üniversitesi T p Fakültesi Dergisi. AVES Yay nc l k taraf ndan bas lm t r. HerSon y llarda görülme s kl yeniden artan tüberküloz, ülkemiz için halen önemli bir toplum sa l sorunudur. zoniazid, ucuz ve etkin olmas nedeniyle en s k kullan lan antitüberküloz ilaçlardan biridir. Yüksek dozlarda al nd nda konvülsiyon, metabolik asidoz, laktik asidoz, rabdomiyoliz, koma ve hatta ölümle sonuçla-nabilir. Temel tedavi al nan izoniazide e dozda verilen parenteral piridoksin uygulamas d r. Burada konvülsiyon geçirdi i için getirilen üç olgu sunulmu olup, izoniazid zehirlenmesinin klinik ve metabolik bulgular ile tedavi yakla m n n tart lmas amaçlanm t r.

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Pyridoxine in clinical toxicology: a review

Cited by 125 publications

References 41 publications

B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity

B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity

The beneficial effect of metadoxine (pyridoxine-pyrrolidone-carboxylate) in the treatment of fatty liver diseases

Isoniazid Overdose: Three Cases Reports

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