Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes

Jain, Sushil K.; Lim, Gideon

doi:10.1016/s0891-5849(00)00462-7

Cited by 216 publications

(124 citation statements)

References 41 publications

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“…PDX2 together with PDX1 form a Gln amidotransferase complex involved in vitamin B6 biosynthesis (Tambasco-Studart et al, 2005). Vitamin B6 has been shown to be a potent antioxidant with the ability to quench ROS such as singlet oxygen and superoxide in human erythrocytes (Jain and Lim, 2001) and fungus (Ehrenshaft et al, 1999) and prevents lipid peroxidation in human erythrocytes (Jain and Lim, 2001). Presumably, vitamin B6 could also protect photosynthetic membranes against lipid peroxidation caused by ROS production during high light stress.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Gene Expression Analysis Reveals a Critical Role for CRYPTOCHROME1 in the Response of Arabidopsis to High Irradiance

et al. 2007

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Exposure to high irradiance results in dramatic changes in nuclear gene expression in plants. However, little is known about the mechanisms by which changes in irradiance are sensed and how the information is transduced to the nucleus to initiate the genetic response. To investigate whether the photoreceptors are involved in the response to high irradiance, we analyzed expression of EARLY LIGHT-INDUCIBLE PROTEIN1 (ELIP1), ELIP2, ASCORBATE PEROXIDASE2 (APX2), and LIGHT-HARVESTING CHLOROPHYLL A/B-BINDING PROTEIN2.4 (LHCB2.4) in the phytochrome A (phyA), phyB, cryptochrome1 (cry1), and cry2 photoreceptor mutants and long hypocotyl5 (hy5) and HY5 homolog (hyh) transcription factor mutants. Following exposure to high intensity white light for 3 h (1,000 mmol quanta m 22 s 21 ) expression of ELIP1/2 and APX2 was strongly induced and LHCB2.4 expression repressed in wild type. The cry1 and hy5 mutants showed specific misregulation of ELIP1/2, and we show that the induction of ELIP1/2 expression is mediated via CRY1 in a blue light intensity-dependent manner. Furthermore, using the Affymetrix Arabidopsis (Arabidopsis thaliana) 24 K Gene-Chip, we showed that 77 of the high lightresponsive genes are regulated via CRY1, and 26 of those genes were also HY5 dependent. As a consequence of the misregulation of these genes, the cry1 mutant displayed a high irradiance-sensitive phenotype with significant photoinactivation of photosystem II, indicated by reduced maximal fluorescence ratio. Thus, we describe a novel function of CRY1 in mediating plant responses to high irradiances that is essential to the induction of photoprotective mechanisms. This indicates that high irradiance can be sensed in a chloroplast-independent manner by a cytosolic/nucleic component.

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Section: Discussionmentioning

confidence: 99%

Genome-Wide Gene Expression Analysis Reveals a Critical Role for CRYPTOCHROME1 in the Response of Arabidopsis to High Irradiance

et al. 2007

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“…Several H 2 O 2 -specific or super-induced genes are involved in riboflavin (vitamin B6) and pyridoxine (vitamin B2) use or synthesis, suggesting an increased requirement for the B vitamin-derived coenzymes and pyridoxal phosphate. Relatively little is known about the antioxidant potential of B vitamins, although recent studies have shown that pyridoxine can quench singlet oxygen and protect against superoxide mediated damage in diabetic patients (Bilski et al, 2000;Jain and Lim, 2001).…”

Section: The Specific Environmental Stress Response (Sesr)mentioning

confidence: 99%

Global Transcriptional Responses of Fission Yeast to Environmental Stress

Chen

Toone

Mata

et al. 2003

MBoC

734

988

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We explored transcriptional responses of the fission yeast Schizosaccharomyces pombe to various environmental stresses. DNA microarrays were used to characterize changes in expression profiles of all known and predicted genes in response to five stress conditions: oxidative stress caused by hydrogen peroxide, heavy metal stress caused by cadmium, heat shock caused by temperature increase to 39°C, osmotic stress caused by sorbitol, and DNA damage caused by the alkylating agent methylmethane sulfonate. We define a core environmental stress response (CESR) common to all, or most, stresses. There was a substantial overlap between CESR genes of fission yeast and the genes of budding yeast that are stereotypically regulated during stress. CESR genes were controlled primarily by the stress-activated mitogen-activated protein kinase Sty1p and the transcription factor Atf1p. S. pombe also activated gene expression programs more specialized for a given stress or a subset of stresses. In general, these "stress-specific" responses were less dependent on the Sty1p mitogen-activated protein kinase pathway and may involve specific regulatory factors. Promoter motifs associated with some of the groups of coregulated genes were identified. We compare and contrast global regulation of stress genes in fission and budding yeasts and discuss evolutionary implications.

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“…Lower PLP levels were linked with inflammation and higher oxidative stress in older Peurto Rican Adults [33]. B6 is a strong quencher of singlet oxygen and can reduce lipid peroxidation [54][55][56]. B6 deficiency has been linked to increased lipid peroxidation and activation of glutathione dependent enzyme [56].…”

Section: Discussionmentioning

confidence: 99%

Impaired recovery of hind limb muscle perfusion following ischemic injury in rodents receiving B vitamin supplementation

Lee¹,

Desjardins²,

Sorokin³

et al. 2017

Blood Heart Circ

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Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes

Cited by 216 publications

References 41 publications

Genome-Wide Gene Expression Analysis Reveals a Critical Role for CRYPTOCHROME1 in the Response of Arabidopsis to High Irradiance

Genome-Wide Gene Expression Analysis Reveals a Critical Role for CRYPTOCHROME1 in the Response of Arabidopsis to High Irradiance

Global Transcriptional Responses of Fission Yeast to Environmental Stress

Impaired recovery of hind limb muscle perfusion following ischemic injury in rodents receiving B vitamin supplementation

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