Pyridoxamine protects human granulosa cells against advanced glycation end-products-induced steroidogenesis disturbances

Mirani, Maryam; Bahmanpour, Soghra; Masjedi, Fatemeh; Derakhshan, Zahra; Dara, Mahintaj; Nasr-Esfahani, Mohammad Hossein; Tabei, Seyed Mohammad Bagher

doi:10.1007/s11033-023-08723-8

Cited by 4 publications

(1 citation statement)

References 58 publications

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“…The synthesis of albumen, which provides the developing embryo protection and essential nutrients, is aided by riboflavin. Sufficient vitamin B2 may increase the quality of the eggs and the viability of the embryos ( Mirani et al, 2023 ). These findings are in line with the results of Florian et al (2021) and Leiber et al (2022) , who discovered that when hens were fed 3.1 mg of riboflavin per kg of diet and 4 mg of vitamin B2 per kg of feed, significantly ( P < 0.05) improve in the weight of chicks and the hatchability of the entire egg set (%) and fertile eggs percentage in comparison to the control group.…”

Section: Resultsmentioning

confidence: 99%

Effects of immersing Japanese quail eggs in various doses of riboflavin on reproductive, growth performance traits, blood indices and economics

Gomaa,

Rashwan,

Tewfik

et al. 2024

Poultry Science

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Section: Resultsmentioning

confidence: 99%

Effects of immersing Japanese quail eggs in various doses of riboflavin on reproductive, growth performance traits, blood indices and economics

Gomaa,

Rashwan,

Tewfik

et al. 2024

Poultry Science

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Advanced Glycation End-Products of Follicular Fluid are Associated with Embryo Morphokinetic Parameters and ART Outcomes

Roushenas,

Izadi,

Jafarpour

et al. 2024

Reprod. Sci.

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Taurine, alpha lipoic acid and vitamin B6 ameliorate the reduced developmental competence of immature mouse oocytes exposed to methylglyoxal

Mokhtari,

Mahdavi,

Jafarpour

et al. 2024

Sci Rep

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Advanced glycation end products (AGEs) are the final products of the Maillard reaction, formed through the interaction of carbohydrates and proteins. Reactive dicarbonyl compounds such as methylglyoxal (MGO) serve as precursors for AGEs formation. Elevated levels of MGO/AGEs are observed in conditions like obesity, polycystic ovarian syndrome (PCOS), and diabetes, negatively impacting oocyte development. Previous studies have shown that hydrogen sulfide, a gasotransmitter with anti-AGEs effects, is produced in a process influenced by vitamin B6. R-α-lipoic acid (ALA) inhibits protein glycation and AGEs formation while stimulating glutathione (GSH) production. Taurine mitigates oxidative stress and acts as an anti-glycation compound, preventing in vitro glycation and AGEs accumulation. This study aimed to explore the ameliorative effects of a micronutrient support (Taurine, ALA and B6: TAB) on mouse oocytes challenged with MGO. Our results indicate that MGO reduces oocyte developmental competence, while TAB supplementation improves maturation, fertilization, and blastocyst formation rates. TAB also restores cell lineage allocation, redox balance and mitigates mitochondrial dysfunction in MGO-challenged oocytes. Furthermore, cumulus cells express key enzymes in the transsulfuration pathway, and TAB enhances their mRNA expression. However, TAB does not rescue MGO-induced damage in denuded oocytes, emphasizing the supportive role of cumulus cells. Overall, these findings suggest that TAB interventions may have significant implications for addressing reproductive dysfunctions associated with elevated MGO/AGEs levels. This study highlights the potential of TAB supplementation in preserving the developmental competence of COCs exposed to MGO stress, providing insights into mitigating the impact of dicarbonyl stress on oocyte quality and reproductive outcomes.

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Pyridoxamine protects human granulosa cells against advanced glycation end-products-induced steroidogenesis disturbances

Cited by 4 publications

References 58 publications

Effects of immersing Japanese quail eggs in various doses of riboflavin on reproductive, growth performance traits, blood indices and economics

Effects of immersing Japanese quail eggs in various doses of riboflavin on reproductive, growth performance traits, blood indices and economics

Advanced Glycation End-Products of Follicular Fluid are Associated with Embryo Morphokinetic Parameters and ART Outcomes

Taurine, alpha lipoic acid and vitamin B6 ameliorate the reduced developmental competence of immature mouse oocytes exposed to methylglyoxal

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