Pyridoxal phosphate as an antisickling agent in vitro.

Reactive Species in Sickle Cell Disease

“…Flores et al found no difference in plasma pyridoxal‐5‐phosphate levels in patients with sickle cell disease compared to black controls, 106 although the mean concentration in both of these groups were significantly lower than that of white children. Theoretically, supplementation with pyridoxine could be beneficial in sickle cell disease not only for its potential effects on plasma homocysteine concentrations, but also because pyridoxal‐5‐phosphate forms a Schiff base with the amino terminal end of the hemoglobin β chain, thus potentially inhibiting hemoglobin polymerization 108. However, in vitro experiments have shown that there is a slight increase in blood viscosity following the addition of pyridoxal‐5‐phosphate 107.…”

Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity

“…Vitamin B6 (pyridioxine) is a vitamin that is essential for heme synthesis and has an antisickling effect on red blood cells by modification of hemoglobin S . Studies suggest that patients with SCD are at an increased risk for vitamin B6 deficiency .…”

“…They generally have darker skin tones, causing them to have an increased risk of deficiency because they require more sunlight exposure to produce sufficient vitamin D. [26] Yet, this is not the sole cause for decreased vitamin D in children with Abbreviations: CHEO, Children's Hospital of Eastern Ontario; SCD, sickle cell disease; VOC, vaso-occlusive crises SCD, as vitamin D levels in children with SCD are significantly lower than African-American children without SCD (5.3 times lower chance of deficiency in the SCD group). [26] Vitamin B6 (pyridioxine) is a vitamin that is essential for heme synthesis and has an antisickling effect on red blood cells by modification of hemoglobin S. [27] Studies suggest that patients with SCD are at an increased risk for vitamin B6 deficiency. [11,14,28] Vitamin B12 (cobalamin) is another vitamin that is needed for normal blood formation.…”

Nutrition and sickle cell disease

“…Pyridoxal phosphate, when present in high concentration, inhibits the gelation of deoxyhemoglobinS and reduces the number of sickled forms that are observed[69]. Pyridoxine increases oxygen affinity of hemoglobin S [66-691.…”