Pyridonecarboxylic acids as antibacterial agents. Part XIII. Regioselective displacement reactions of 1-cyclopropyl-5,6,7,8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylic acid with amine nucleophiles.

Shibamori, K.; Egawa, Hiroshi; Miyamoto, Teruyuki; Nishimura, Yoshihiko; Itokawa, Akira; Nakano, Junji; Matsumoto, Junichi

doi:10.1248/cpb.38.2390

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C−f Bond Activation In Aromatic Fluorides1

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“…The reaction sequences involving regioselective nucleophilic displacement of polyfluorinated arenes are brilliant methodologies to produce quinolone carboxylic acid derivatives. Scheme shows the summary of actual routes to quinolone antibacterial agents, levofloxacin ( 319 ), pazufloxacin ( 320 ), and sparfloxacin ( 322 ) …”

Section: C−f Bond Activation In Aromatic Fluoridesmentioning

confidence: 99%