Pyridines in Alzheimer's disease therapy: Recent trends and advancements

Mishra, Puja; Basak, Souvik; Mukherjee, Arup; Ghosh, Balaram

doi:10.1016/b978-0-323-91221-1.00001-4

Cited by 2 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pyridine, a nitrogen-containing heteroarene, is a pervasive privileged substructure found in various pharmaceuticals and natural products 1,2 . The intricate interplay between pyridine's biological relevance and substitution patterns has led to the emergence of numerous bioactive compounds [3][4][5][6][7][8] . Consequently, developing e cient synthetic methods for selectively functionalized pyridines has become crucial in synthetic chemistry.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the concealed reactivity of masked diformylmethane with RAHB-assisted enamines leads to dissymmetric di-meta-substituted pyridines

Park,

Yi,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

Pyridine, an essential structure in drug development, shows a wide array of bioactivities according to its substitution patterns. Among the bioactive pyridines, meta-substituted pyridines suffer from limited synthetic approaches despite their significance. In this study, we present a novel synthetic method enabling the facile incorporation of biologically relevant functional groups at the meta position of pyridine. This methodology unveiled the concealed reactivity of 3-formyl(aza)indoles as diformylmethane analogs for synthesizing dissymmetric di-meta-substituted pyridines without ortho and para substitutions. Furthermore, we uncovered resonance-assisted hydrogen bonding (RAHB) as the requirement for the in-situ generation of enamines, the key intermediates of this transformation. Successful development of the designed methodology linked to wide applications—core remodeling of natural products, drug–natural product conjugation, late-stage functionalization of drug molecules, and synthesis of an unprecedented regioisomer of CZC24832. Furthermore, we discovered anti-inflammatory agents through the functional evaluation of synthesized bi-heteroaryl analogs, signifying the utility of this methodology.

show abstract

Section: Introductionmentioning

confidence: 99%

Unveiling the concealed reactivity of masked diformylmethane with RAHB-assisted enamines leads to dissymmetric di-meta-substituted pyridines

Park,

Yi,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Unveiled reactivity of masked diformylmethane with enamines forming resonance-assisted hydrogen bonding leads to di-meta-substituted pyridines

Yi,

Lee,

Cho

et al. 2024

Commun Chem

View full text Add to dashboard Cite

Pyridine, an essential structure in drug development, shows a wide array of bioactivities according to its substitution patterns. Among the bioactive pyridines, meta-substituted pyridines suffer from limited synthetic approaches despite their significance. In this study, we present a condensation-based synthetic method enabling the facile incorporation of biologically relevant functional groups at the meta position of pyridine. This methodology unveiled the concealed reactivity of 3-formyl(aza)indoles as diformylmethane analogs for synthesizing dissymmetric di-meta-substituted pyridines without ortho and para substitutions. Furthermore, we uncovered resonance-assisted hydrogen bonding (RAHB) as the requirement for the in situ generation of enamines, the key intermediates of this transformation. Successful development of the designed methodology linked to wide applications—core remodeling of natural products, drug–natural product conjugation, late-stage functionalization of drug molecules, and synthesis of the regioisomeric CZC24832. Furthermore, we discovered anti-inflammatory agents through the functional evaluation of synthesized bi-heteroaryl analogs, signifying the utility of this methodology.

show abstract

Pyridines in Alzheimer's disease therapy: Recent trends and advancements

Cited by 2 publications

References 57 publications

Unveiling the concealed reactivity of masked diformylmethane with RAHB-assisted enamines leads to dissymmetric di-meta-substituted pyridines

Unveiling the concealed reactivity of masked diformylmethane with RAHB-assisted enamines leads to dissymmetric di-meta-substituted pyridines

Unveiled reactivity of masked diformylmethane with enamines forming resonance-assisted hydrogen bonding leads to di-meta-substituted pyridines

Contact Info

Product

Resources

About