Pyridines and their Benzo Derivatives: Synthesis

Jones, Gurnos

doi:10.1016/b978-008096518-5.00108-8

Cited by 146 publications

(14 citation statements)

References 457 publications

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“…Leszek Łobocki for measurements of mass spectra (MALDI TOF). Scientists the world over have been interested in quaternary ammonium compounds (QACs) for over a hundred years (Jones, 1984;Śliwa, 1996Śliwa, , Sajomsang et al, 2009Obłąk & Gamian, 2010). These salts display both inorganic properties (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…For background to quaternary ammonium compounds, see: Jones (1984);Ś liwa (1996); Sajomsang et al (2009);Obłąk & Gamian (2010); Binks et al (2011);Singh et al (2009);CruzGuzman et al (2005); Rabea et al (2003); Belalia et al, 2008;McDonnell & Russell (1999); Boethling (1984); Levinson (1999); Cross & Singer (1994). For QAC sugar derivatives, see: Abel et al (2002); Blizzard et al (2002); Honda et al (1988); Thomas et al (2009) ;Maslov et al (2010); Dmochowska et al (2006Dmochowska et al ( , 2009Dmochowska et al ( , 2011Pellowska-Januszek et al (2004); Skorupa et al (2004).…”

Section: Related Literaturementioning

confidence: 99%

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N,N,N-Trimethyl-N-(methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosid-5-yl)ammonium 4-methylbenzenesulfonate sesquihydrate

et al. 2013

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Key indicators: single-crystal X-ray study; T = 200 K; mean (C-C) = 0.005 Å; some non-H atoms missing; disorder in main residue; R factor = 0.051; wR factor = 0.139; data-to-parameter ratio = 15.8.The structure of the title compound, [C 12 H 24 NO 4 ][C 7 H 7 O 3 S]Á-1.5H 2 O, contains alternating layers parallel to (001) of hydrophobic and polar character, stabilized by C-HÁ Á ÁO hydrogen bonding. The furan ring adopts an envelope conformation with the C(OMe) atom as the flap, and the dioxolane ring is twisted about one of the O-C(methine) bonds. A comparison to related compounds is presented. The tosylate-O atoms were disordered over two positions with the major component having a site occupancy factor = 0.566 (12). The structure was refined as a rotary twin with regard to rotation about the c axis with the contribution of the second component being 0.0048 (6). Solvate water molecules are highly disordered and were removed using the SQUEEZE procedure; the unit cell characteristics take into account the presence of the disordered solvent. High-resolution 1 H and 13 C NMR spectroscopic data are also presented. Related literature

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Section: Methodsmentioning

confidence: 99%

Section: Related Literaturementioning

confidence: 99%

N,N,N-Trimethyl-N-(methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosid-5-yl)ammonium 4-methylbenzenesulfonate sesquihydrate

et al. 2013

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“…They also form the basic structural elements of a number of important metabolites. [2] In addition, functionalized pyridones are very important in pharmaceutical chemistry and the agrochemical industry, [3] and their analogues are widely used as versatile intermediates in the synthesis of a variety of aza-heterocycles, such as, pyridine, piperidine, quinolizidine, and indolizidine alkaloids. [4,5] Considering the importance of compounds with these structural units, the development of an efficient approach for the synthesis of pyridin-1(2H)-ones is therefore desirable.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of the N‐Substituted Pyridin‐1(2H)‐one Framework by Ligand‐Assisted Pd‐Catalyzed Reactions

et al. 2012

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“…[2] Substituted pyridin-2(1H)-one compounds are of high importance in pharmaceuticals because they are increasingly used in the treatment of malaria, asthma, and epilepsy, and form the basic structural elements of a number of important metabolites. [3] Despite their importance, the various methods available to synthesize these derivatives are problematic, particularly for N-substituted pyridin-2(1H)-one analogues. Extensive work has been carried out by researchers to overcome the synthetic difficulties by utilizing organic transformations.…”

Section: Introductionmentioning

confidence: 99%