Pyridine-based polymers and derivatives: Synthesis and applications

Competitive Adsorption of Phenolic Acids, Secoiridoids, and Flavonoids in Quercetin Molecularly Imprinted Polymers and Application for Fractionation of Olive Leaf Extracts

“…Herein is reported the development of tailored polymer networks joining functionalization with 4-vinylpyridine (4VP) and molecular imprinting with quercetin as a template. 4VP was considered for functional monomer due to its special binding features that grounds the specific use for the development of advanced polymers in a wide range of applications (wastewater/industrial effluents treatment, enzyme/protein adsorption, electronics, biomedicine, or catalysis − ), including also adsorbents for plant extracts in view of the strong binding with phenolic compounds. − , The rationale for the selection of quercetin is based on its reference structure for many flavonoid molecules and because it is widely available (present in many plants) and is a less expensive molecule, therefore working as a kind of surrogate for flavonoids. Note that, in spite of a possible imperfect selectivity of MIPs and a likely high retention also observed with the correspondent NIPs (non-imprinted polymers) or functional commercial adsorbents, a positive impact of molecular imprinting was demonstrated, not only on specific binding sites formation but also on the improvement of the morphology and textural properties of the adsorbents. − …”

Fractionation of flavonols and anthocyanins in winemaking residues using molecularly imprinted cellulose‐synthetic hybrid particles with pyridyl active surface

“…Indeed, pyridine and the pyridyl group behave as proton acceptors, being weak bases (pKa = 5.22 for pyridine) and also as a good ligand for multiple metal ions, giving rise to complexation. [ 1 ] Actually, pyridine‐based polymers are used in practice as advanced materials in a wide range of domains, including the treatment of wastewater and industrial effluents (e.g. copper, nickel, chromium and mercury adsorption), noble metals recovery (e.g., gold adsorption from aqueous solutions or uranium capture in nuclear plants), enzymes/protein adsorption, electronics (e.g.…”

“…light‐emitting devices, sensors and electrochemical applications), biomedicine, or even catalysis. [ 1–8 ] The sorption of phenolic contaminants with pyridine‐based polymers was also considered some decades ago [ 9–11 ] and the outperformance of the pyridine‐based adsorbents, namely in comparison with styrene‐DVB copolymers was observed. [ 1 ]…”

“…[1][2][3][4][5][6][7][8] The sorption of phenolic contaminants with pyridine-based polymers was also considered some decades ago [9][10][11] and the outperformance of the pyridine-based adsorbents, namely in comparison with styrene-DVB copolymers was observed. [1] Notably, adsorbents with pyridyl moieties present also a strong binding with phenolic compounds in different kinds of plant extracts and are being considered for valorization of these classes of bioactive compounds. [12][13][14][15][16][17][18] Actually, multivalent hydrogen bonding of the phenolic groups in polyphenols (e.g.…”

Deoxygenation of heterocyclic N-oxides employing iodide and formic acid as a sustainable reductant

“…1a), 3 and materials science. 4 In consequence, compounds containing N -pyridinic moieties are among the most commonly used in the manufacture of drug candidates. 5 Unfortunately, the direct functionalization of pyridines and their derivatives through direct electrophilic substitutions imposes a challenge due to poor chemoselectivity and a lower π-system energy compared to benzene.…”