Pyridine-2,6-dihydroxamic acid, a powerful dihydroxamate ligand for Ni²⁺and Cu²⁺ions

A HTS Assay for the Detection of Organophosphorus Nerve Agent Scavengers

“…The crude product was diluted in EtOAc (10 mL), washed with water (2 10 mL), dried over Na 2 SO 4 2-Oxo-2-(pyridin-2-yl)acetaldehyde oxime (37): Oximes at the a position of a ketone were obtained by the reaction of the carbonyl compound with an alkyl nitrite in the presence of a base. [59] Thus, the expected compound 37 could be isolated by treating isoamyl nitrite with 2-acetylpyridine in the presence of potassium tert-butoxide in toluene, but a poor yield of only 10 % was obtained (Scheme 7). As the quantity of the product obtained (~135 mg) was sufficient to realise the hydrolysis tests, this reaction was not further optimised.…”

Monohydroxamic acids and bridging dihydroxamic acids as chelators to ruthenium(iii) and as nitric oxide donors: syntheses, speciation studies and nitric oxide releasing investigation

“…A Ni II (2,6-pyha) complex has been reported where the dihydroxamato ligand chelates the Ni II ion via the {N,N py ,N} donor set to give a discrete mononuclear [PPh 4 ] 2 [Ni(2,6-pyha) 2 ]•7H 2 O complex. 25 Another report describes the use of 1,3-benzodihydroxamic acid (L) in the construction of an Fe 4 L 6 pyramid and consequently a three-dimensional porous metal-organic framework. 26 Herein, we report reaction of the dihydroxamic acids, 1,3-bhaH 2 , 1,4-bhaH 2 and 2,6-pyhaH 2 with 2 equivalents of K[Ru(Hedta)Cl], which affords novel dinuclear Ru III -dihydroxamato complexes [{Ru(H 2 edta)} 2 (l-1,3-bha)], [{Ru(H 2 edta)} 2 (l-1,4-bha)] and [{Ru(H 2 edta)} 2 (l-2,6-pyha)], respectively (Fig.…”

Ethyl 6-(hydroxymethyl)picolinate

“…2,6-Disubstituted pyridine derivatives are very useful ligands for the construction of metal complexes (Mohamed & El-Gamel, 2005;Alcock et al, 2005;Joensson et al, 2004). The title compound, (I), can be used directly to coordinate transitionmetal atoms (Kapoor et al, 2004;Goher et al, 2003;Swiatek-Kozlowska et al, 2002). We report here its crystal structure.…”