Pyridazine, oxazine, pyrrole, and pyrrolo[1,2‐<i>a</i>]quinazoline derivatives from malononitrile dimer

El‐Din, Abdellatif M. Salah

doi:10.1002/hc.10199

Cited by 13 publications

(2 citation statements)

References 12 publications

(17 reference statements)

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“…[18][19][20][21][22][23][24][25][26][27][28][29][30] Noticing the availability of the 2-aminobenzophenones in the synthesis of certain heterocycles, Garcia et al 24 extended these studies to pyrrole and pyrrolo-fused derivatives. Thus, starting from …”

Section: Syntheses Starting From N-arylpyrrolesmentioning

confidence: 99%

Pyrrolo[1,2-a]quinazolines: synthesis and biological properties

Dumitraşcu¹,

Popa²

2014

Arkivoc

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Pyrrolo[1,2-a]quinazolines have raised some interest as bioactive scaffolds but their synthetic strategies based mainly on the anthranilic acid route have been rather limited. The last two decades have brought new approaches to the synthesis of pyrrolo[1,2-a]quinazoline framework and thus their potential could be valued in the obtaining of new lead compounds from the important class of quinazolines. Herein we present the synthetic strategies towards compounds containing the pyrrolo[1,2-a]quinazoline scaffold and their biological properties.

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Section: Syntheses Starting From N-arylpyrrolesmentioning

confidence: 99%

Pyrrolo[1,2-a]quinazolines: synthesis and biological properties

Dumitraşcu¹,

Popa²

2014

Arkivoc

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“…Omeprazole 3 and Pimobendan 4 that are therapeutically useful in the management of peptic ulcer and congestive heart failure, respectively. Many derivatives of benzimidazoles are well known for their antimicrobial, [5][6][7][8][9][10] anthelmintic, 11 antiviral, [12][13][14][15][16] and antifungal 17,18 activities. Since 1985 benzimidazole containing compounds have been reported as well known anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

New approaches for the synthesis, cytotoxicity and toxicity of heterocyclic compounds derived from 2-cyanomethyl benzo[c]imidazole

Mohareb

Mohamed²,

Abdallah³

2016

ACSi

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The reaction of ethyl cyanoacetate with o-phenylenediamine gave the 2-cyanomethylbenzo[c]imidazole (1). The latter compound was used as the key starting material to synthesise biologically active heterocyclic derivatives. Thus, the reaction of 1 with cyclohexanone and either of benzaldehyde, 4-methoxybenzaldehyde or 4-chlorobenzaldehyde gave the annulated derivatives 2a-c, respectively. The antitumor evaluations of the newly synthesized products against the three cancer cell lines MCF-7 (breast adeno-carcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer) showed that compounds 2b, 6, 11b, 11c, 12b, 16a, 16b and 18a exhibited optimal cytotoxic effect against cancer cell lines, with IC 50 values in the nM range. Bioactive compounds are often toxic to shrimp larvae. Thus, in order to monitor these chemicals in vivo lethality to shrimp larvae (Artemia salina), Brine-Shrimp Lethality Assay was used. Compounds 11b, 12b and 16b showed no toxicity against the tested organisms.

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Pyridazine, Oxazine, Pyrrole, and Pyrrolo[1,2‐a]quinazoline Derivatives from Malononitrile Dimer.

El‐Din

2004

ChemInform

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Pyridazine, oxazine, pyrrole, and pyrrolo[1,2‐a]quinazoline derivatives from malononitrile dimer

Cited by 13 publications

References 12 publications

Pyrrolo[1,2-a]quinazolines: synthesis and biological properties

Pyrrolo[1,2-a]quinazolines: synthesis and biological properties

New approaches for the synthesis, cytotoxicity and toxicity of heterocyclic compounds derived from 2-cyanomethyl benzo[c]imidazole

Pyridazine, Oxazine, Pyrrole, and Pyrrolo[1,2‐a]quinazoline Derivatives from Malononitrile Dimer.

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