Pyrethroids and developmental neurotoxicity - A critical review of epidemiological studies and supporting mechanistic evidence

Andersen, Helle Raun; David, Arthur; Freire, Carmen; Fernández, Mariana F.; D’Cruz, Shereen Cynthia; Reina-Pérez, Iris; Fini, Jean-Baptiste; Bláha, Luděk

doi:10.1016/j.envres.2022.113935

Cited by 42 publications

(19 citation statements)

References 107 publications

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“…Both can act as estrogen receptor agonists and promote estrogen receptor production. Besides, strong evidence proves that pyrethroid is also a thyroid hormone disruptor and has the hormone-like activity to interfere with reproduction [ 49 ]. Except for the endocrine way, pyrethroids can modify the expression of ovarian miRNAs to interfere with ovarian development and maturation more directly [ 50 ].…”

Section: Mechanisms and Hazards Of Pesticidesmentioning

confidence: 99%

Degradation strategies of pesticide residue: From chemicals to synthetic biology

Ruomeng

Meihao

Siru

et al. 2023

Synthetic and Systems Biotechnology

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Section: Mechanisms and Hazards Of Pesticidesmentioning

confidence: 99%

Degradation strategies of pesticide residue: From chemicals to synthetic biology

Ruomeng

Meihao

Siru

et al. 2023

Synthetic and Systems Biotechnology

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“…Like many other insecticide compounds, pyrethroids are known to be neurotoxic [ 15 ]. In fact, intraperitoneal injection of 3-PBA in mice daily for 2 months has shown to induce synuclein aggregation in dopaminergic neurons, which may contribute to dopaminergic neurodegeneration [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, a recent review provides relevant evidence which confirms that pyrethroids exposure during pregnancy may impact neurodevelopment for example by interference with thyroid hormone (TH) function [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

Guimarães

Bracchi

Pinheiro

et al. 2023

Toxics

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The aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) µg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features.

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“…The prevalence of chlorpyrifos use on crops worldwide is in the 5–39% range [ 26 ]. During the last decade, pyrethroids use has also increased to replace other more toxic pesticides and represents 38% of the world insecticide market [ 27 ]. In Uruguay, 38,000 tons of pesticides (pyrethroids and chlorpyrifos among others) were produced in 2012 [ 2 ]; many of these present high levels of toxicity, and more than 85% of the active ingredients used are imported [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Pyrethroid and Chlorpyrifos Pesticide Exposure, General Intellectual Abilities, and Executive Functions of School Children from Montevideo, Uruguay

Rodríguez

Barg

Queirolo

et al. 2023

IJERPH

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Children’s developing brains are susceptible to pesticides. Less is known about the effect of exposure to chlorpyrifos and pyrethroids on executive functions (EF). We measured urinary 3,5,6-trichloro-2-pyridinol (TCPy), a metabolite of chlorpyrifos, and urinary 3-phenoxybenzoic acid (3-PBA), a general, nonspecific metabolite of pyrethroids in first-grade children from Montevideo, Uruguay (n = 241, age 80.6 ± 6.4 months, 58.1% boys). EFs were assessed with the Intra-dimensional/Extra-dimensional shift (IED), Spatial Span (SSP), and Stockings of Cambridge (SOC) tests from the Cambridge Neuropsychological Test Automated (CANTAB) Battery. General intellectual ability (GIA) was assessed using the Woodcock–Muñoz Cognitive battery. Median (range) urinary TCPy and 3-PBA levels were 16.7 (1.9, 356.9) ng/mg of creatinine and 3.3 (0.3, 110.6) ng/mg of creatinine, respectively. In multivariable generalized linear models, urinary TCPy was inversely associated with postdimensional errors on the IED task β [95% CI]: −0.11 [−0.17, −0.06]. Urinary 3-PBA was inversely associated with the total number of trials −0.07 [−0.10, −0.04], and the total number of errors −0.12 [−0.18, −0.07] on the IED task. When TCPy and 3-PBA were modeled together, the associations did not differ from single-metabolite models. We found no evidence of effect modification by blood lead level (BLL). Pesticide exposure may affect EF performance in urban children.

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Pyrethroids and developmental neurotoxicity - A critical review of epidemiological studies and supporting mechanistic evidence

Cited by 42 publications

References 107 publications

Degradation strategies of pesticide residue: From chemicals to synthetic biology

Degradation strategies of pesticide residue: From chemicals to synthetic biology

Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

Pyrethroid and Chlorpyrifos Pesticide Exposure, General Intellectual Abilities, and Executive Functions of School Children from Montevideo, Uruguay

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