Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573

Hashida, Junko; Niitsuma, Megumi; Iwatsuki, Masato; Mori, Masayuki; Ishiyama, Aki; Namatame, Miyuki; Nishihara‐Tsukashima, Aki; Nonaka, Kenichi; Ui, Hideaki; Masuma, Rokuro; Otoguro, Kazuhiko; Yamada, Hideaki; Shiomi, Kazuro; Ōmura, Satoshi

doi:10.1038/ja.2010.65

Cited by 22 publications

(14 citation statements)

References 12 publications

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“…[3][4][5] Our ongoing studies have led to the discovery of two novel NFAT-133 analogs, panowamycins A (1) and B (2) isolated from a culture broth of Streptomyces sp. K07-0010, along with NFAT-133 (3), 6 conglobatin (4), 7 piericidins C 1 -C 4 (5-8) 8 and dinactin (11) 9 ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

et al. 2012

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Two new isochromans, panowamycins A and B, were purified by solvent extraction, silica gel and octadecylsilyl silica gel (ODS) column chromatography followed by preparative HPLC, from a culture broth of Streptomyces sp. K07-0010, together with the known compounds NFAT-133, conglobatin, piericidin C series and dinactin. Structures of panowamycins were elucidated as new analogs of NFAT-133 by spectroscopic studies including various NMR experiments. Panowamycins A and B showed moderate antitrypanosomal activity, with IC 50 values of 0.40 and 3.30 lg ml -1 , respectively.

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Section: Introductionmentioning

confidence: 99%

Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

et al. 2012

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“…During the course of our screening program for compounds that treat the disease, which is caused by the parasite T. brucei, we have reported on various natural products, such as microbial metabolites and plant products that exhibit potent antitrypanosomal properties. [2][3][4][5][6][7][8] This time we focused on metabolites from cultures of Cordyceps that showed antitrypanosomal activity. Cordyceps is a fungal genus which is endopathogenic with arthropods, principally insects.…”

Section: Introductionmentioning

confidence: 99%

In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832

et al. 2013

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During the search for new antitrypanosomal drug leads, three new antitrypanosomal compounds, cardinalisamides A-C (1-3), were isolated from cultures of the insect pathogenic fungus Cordyceps cardinalis NBRC 103832. Their structures were elucidated using MS analyses and extensive 2D-heteronuclear NMR. The absolute configurations of 1-3 were addressed by chemical degradation and Marfey's analysis. 1-3 showed in vitro antitrypanosomal activity against Trypanosoma brucei brucei with IC50 values of 8.56, 8.65 and 8.63 μg ml(-1), respectively.

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“…continued a similar antitrypanosomal activity against Trypanosoma brucei (IC 50 of 1.8 µg/mL) compared to the commonly used drug suramin, while pyrenocine A (64) showed the most potent activity with an IC 50 value of 0.12 µg/mL [49]. The polyketide-derived compound 69 showed a significant inhibitory effect on the overall growth of the cotton bollworm Helicoverpa armigera, while surprisingly, the terpenoid-derived metabolite 76 significantly promoted the growth of the larvae, revealing that P. cateniobliquus could produce diverse metabolites to regulate the growth of the insect [50].…”

Section: Nomentioning

confidence: 86%

“…The screening of antitrypanosomal agents from microbial metabolites led to the discovery of four α-pyrones (63-66) from Paecilomyces sp. FKI-3573 was collected from a soil sample, of which pyrenocine I (63) was isolated as a new compound [49]. Chemical investigation of the fungus Paecilomyces cateniobliquus YMF1.01799 led to the isolation and identification of four phomalactone-type metabolites (67-70), two of which were new compounds (67 and 68) [50].…”

Section: Polyketidesmentioning

confidence: 99%

“…Paeciloxocin A (40) exhibited strong cytotoxicity against HepG2 cells with an IC 50 value of 1 µg/mL [41]. Two α-pyrones, pyrenocines A (64) and B (65), showed potent cytotoxic activity against a human embryonic lung fibroblast cell line, MRC-5, with IC 50 values of 0.38 and 0.98 µg/mL, respectively [49]. Acetoxyscirpenediol (87) possessed potent cytotoxic activities against the human gastric tumor cell line (SNU-1), human hepatoma cell line (SNU-354), human colorectal tumor cell line (SNU-C4), and murine sarcoma-180 with IC 50 s of 1.2, 4.0, 2.2, and 1.9 µM, respectively [79].…”

Section: Anticancer Activitymentioning

confidence: 99%

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A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

Liu

et al. 2020

Planta Med

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AbstractFungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera Aspergillus, Penicillium, and Talaromyces are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus Paecilomyces, which has been reported to possess great potential for its application as a biocontrol agent. Meanwhile, a wide structural array of metabolites with attractive bioactivities has been reported from this genus. This review attempts to provide a comprehensive overview of Paecilomyces species, with emphasis on the chemical diversity and relevant biological activities of these metabolic products. Herein, a total of 148 compounds and 80 references are cited in this review, which is expected to be beneficial for the development of medicines and agrochemicals in the near future.

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Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573

Cited by 22 publications

References 12 publications

Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832

A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

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