Pyrenecarboxaldehyde@Graphene Oxide Acted as a Highly Efficient ECL Emitter and Target-Triggered the Recyclable Cascade System as an Amplifier for Ultrasensitive APE1 Activity Detection
Duo-Duo Chai,
Ying Zhuo,
Mei-Ling Zhao
et al.
Abstract:Herein, pyrenecarboxaldehyde@graphene oxide (Pyc@GO) sheets with highly efficient electrochemiluminescence (ECL) as emitters were prepared by a noncovalent combination to develop a neoteric ECL biosensing platform for the ultrasensitive assessment of human apurinic/apyrimidinic endonuclease1 (APE1) activity. Impressively, the pyrenecarboxaldehyde (Pyc) molecules were able to form stable polar functional groups on the surface of GO sheets through the noncovalent π−π stacking mechanism to prevent intermolecular … Show more
With their stability, high catalytic activity, ease of synthesis, functionalization and ease of modification, DNAzymes have attracted much attention in the fields of bioimaging, biosensing and cancer therapy.
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