Pyrene-imidazolium complexed graphene for the selective fluorescent detection of G-quadruplex forming DNA

Moon, Seung Jin; Park, So Hyeon; Jaworski, Justyn; Jung, Jong Hwa

doi:10.1039/c3cc46744a

Cited by 7 publications

(6 citation statements)

References 24 publications

(25 reference statements)

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“…Pyrene‐imidazolium derivatives have recently found several applications as fluorescent sensors for ATP, for G‐quadruplex forming DNA, and for lanthanide ions in aqueous solutions …”

Section: Introductionmentioning

confidence: 99%

DNA‐Binding and Anticancer Activity of Pyrene‐Imidazolium Derivatives

et al. 2016

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DNA-binding investigations showed that two different derivatives endowed with pyrene and imidazolium moieties, 1 and 2, strongly bind both double-stranded DNA and telomeric sequences in G-quadruplex (G4) conformation. The values of the DNA-binding constants indicate that 1 and 2 show preferential affinity for G4-DNA, of about one and two orders of magnitude, respectively. Moreover, 1 and 2 inhibit short and long-term proliferation of breast cancer cell lines in a time- and dose-dependent fashion. Remarkably, senescence assays indicate that telomeric G4-DNA is a possible biotarget for the cytotoxic activity of 2. Molecular dynamics simulations suggest that the stronger binding of 2 with G4-DNA and the related senescence induction, are a consequence of additional edge-to-face interactions with a base in the TTA loop

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“…Pyrene‐imidazolium derivatives have recently found several applications as fluorescent sensors for ATP, for G‐quadruplex forming DNA, and for lanthanide ions in aqueous solutions …”

Section: Introductionmentioning

confidence: 99%

DNA‐Binding and Anticancer Activity of Pyrene‐Imidazolium Derivatives

et al. 2016

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“…[4][5][6] More recently, the metallic nanoclusters (NCs) including gold, silver NCs were found to exhibit unique uorescence properties and have been explored for bio-imaging and diagnosis. [7][8][9][10][11][12][13][14][15][16] Platinum nanoclusters (Pt NCs), as one of the most important noble metal NCs, were observed to generate strand breaks in DNA 17 and on the other hand, its insoluble forms possess notable antioxidative capacity and the potentially low cytotoxicity, [18][19][20][21] suggesting its potential for promising bioapplications.…”

mentioning

confidence: 99%

One-step rapid synthesis of fluorescent platinum nanoclusters for cellular imaging and photothermal treatment

Chen

Gao

et al. 2014

RSC Adv.

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“…Jung, Jaworski and coworkers have studied selective fluorescent detection of G‐quadruplex forming DNA using SiO 2 @rGO‐ 138 having pyrene‐imidazolium complexed graphene. The π‐ π stacking between aromatic surface of graphene and 138 resulted in the capture of 138 into the hollow shell of graphene.…”

Section: Recognition Of Large Biomoleculesmentioning

confidence: 99%

Imidazolium Based Probes for Recognition of Biologically and Medically Relevant Anions

et al. 2016

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The imidazolium derivatives due to their positive charge possess one of the most polarized and positively charged proton at C2-H to form strong ionic hydrogen bond (also termed as double ionic hydrogen bond) with anions and also provide opportunities for anion - π interactions with electron-deficient imidazolium ring. In the present review article, imidazolium based molecular probes for their ability to recognize inorganic anions like halides, cyanide, perchlorate, carboxylic acids, phosphate, sulfate etc. and their derived molecules viz. nucleotides, DNA, RNA, surfactants, proteins, etc have been discussed. The review covers the literature published after year 2009 and has > 130 references. The previous literature has already been discussed by Yoon et al. in two review articles published in Chem. Soc. Rev. 2006 and 2010.

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Pyrene-imidazolium complexed graphene for the selective fluorescent detection of G-quadruplex forming DNA

Cited by 7 publications

References 24 publications

DNA‐Binding and Anticancer Activity of Pyrene‐Imidazolium Derivatives

DNA‐Binding and Anticancer Activity of Pyrene‐Imidazolium Derivatives

One-step rapid synthesis of fluorescent platinum nanoclusters for cellular imaging and photothermal treatment

Imidazolium Based Probes for Recognition of Biologically and Medically Relevant Anions

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