Pyrazolotriazines: Biological activities, synthetic strategies and recent developments

Silver(I) Complexes with Mefenamic Acid and Nitrogen Heterocyclic Ligands: Synthesis, Characterization, and Biological Evaluation

“…Furthermore, many drugs contain N-heterocycles, and some have shown biological activity. − When N-heterocyclic compounds form complexes with metals, they also exhibit a variety of biological activities; nitrogen heterocyclic complexes have shown their ability to bind with DNA/BSA and exhibited anticancer activity. − Among them, the metal complexes formed by pyridine derivatives demonstrate good antitumor activity and multiple forms of antitumor applications. − A small amount of metal complexes produced by pyrazine derivatives also display anticancer activity. − …”

Isoxazolyl-Derived 1,4-Dihydroazolo[5,1-c][1,2,4]Triazines: Synthesis and Photochemical Properties

“…1,2,4-Triazine-based compounds and their fused congeners have anticancer, antimicrobial, antifungal, anti-inflammatory, antimalarial, and antiviral properties [ 1 , 2 , 3 , 4 ]. Since 1,2,4-triazines fused with five-membered heterocycles are considered bio-isosteres with a purine core, these derivatives are the focus of drug design [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. However, 1,2,4-triazines possessing specific photophysical properties have seldom been used in optoelectrical research.…”

Regioselective synthesis of new imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazines via reaction of imidazo[4,5‐e][1,2,4]triazinethiones with ethyl phenylpropiolate

“…They proved to be agrochemical growth regulators in Cucumis sativus cultures [11]. In turn, compounds containing a triazine fragment [12][13][14][15] and their fused derivatives, viz. imidazo [4,5-e] [1,2,4]triazines (6-azapurines), are characterized by a wide profile of biological activity [16,17].…”