Pyrazoloquinolines and zolpidem: Effects on hypertonic saline consumption in rehydrating rats

Cooper, Steven J.; Desa, Asmawati

doi:10.1002/ddr.430140207

Cited by 16 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 ~ has anxiolytic-like effects but only in a limited range of tests and only at doses that decrease behavioral output (24,36,53,69). Similarly, increases in food and fluid intake in rodents, which are consistently reported with benzodiazepines, have been reported only rarely with zolpidem (15,18,56,74,81,100). An effect on the learning of an avoidance response was also found in mice only at sedative doses (71).…”

Section: Behavioral Effectsmentioning

confidence: 99%

The Pharmacology and Mechanism of Action of Zolpidem

Sanger¹,

Depoortere²

1998

CNS Drug Reviews

View full text Add to dashboard Cite

Section: Behavioral Effectsmentioning

confidence: 99%

The Pharmacology and Mechanism of Action of Zolpidem

Sanger¹,

Depoortere²

1998

CNS Drug Reviews

View full text Add to dashboard Cite

“…GABA A receptor agonists, antagonists, and inverse agonists have been useful in helping to unravel the role of the specific GABA A receptor subunits in feeding. For example, the compound CGS 17867A binds to α1, α2, and α3 subunits with significantly higher efficacy at the α2, and α3 subunits than the α1 subunit, and intraperitoneal injection of CGS 17867A increased consumption of both highly palatable food and a normally aversive hypertonic NaCl solution in rodents (Cooper and Desa, 1988;Yerbury and Cooper, 1989). This suggests that benzodiazepines with a high affinity for α2 and α3 receptor subunits and low affinity for α1 subunits are most likely to induce hyperphagia (Cooper, 2005).…”

Section: Introductionmentioning

confidence: 99%

Selective stimulation of central GABAAα2,3,5 receptors increases intake and motivation to consume sucrose solution in rats

et al. 2019

View full text Add to dashboard Cite

Benzodiazepines are one of the most commonly prescribed anxiolytic drugs in America, and between 2006 and 2015 prescription rates increased by an estimated 27.1%. Weight gain is a common side effect of these drugs and it may result from increased feeding caused by drugenhanced food palatability. We investigated the role of specific GABA A receptor subtypes involved with benzodiazepine-induced food consumption through third ventricle injections of L-838,417, a partial agonist of GABA A α2, α3, and α5 subunits, and a full antagonist of the α1 receptor subunit. A microanalysis of the licking behavior of adult male rats to a sucrose solution was used to isolate drug effects on specific consummatory behaviors that include: hedonic taste evaluation, food approach behavior, and oromotor function. L-838,417 dose-dependently increased intake through increases in the motivation to approach the solution (shorter pause intervals between bouts of licking) and through enhancement of measures associated with hedonic taste evaluation. Oromotor depressant effects previously associated with broad-spectrum benzodiazepine receptor agonists were not observed. These results indicate that nuclei in proximity to the ventricles respond to GABA A α2, α3, or α5 activation to induce motivation to feed, absent of α1 receptor subunit activation. Furthermore, activation of the α1 subunit is not necessary for benzodiazepine hyperphagia and may instead contribute to the oromotor depressant and sedative properties of classic benzodiazepine agonists. Hypothalamic nuclei such as the paraventricular nucleus may be involved in the benzodiazepine-increased motivation to feed, while

show abstract

Effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid consumption in the rat

et al. 1993

View full text Add to dashboard Cite

Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in water). The increase in fluid consumption induced with zolpidem was comparable to the increases observed with diazepam and the benzodiazepine partial agonist, FG 8205. Experiment 2 demonstrated that this zolpidem-induced increase in drinking could be observed in both naive rats and in rats that had been habituated to the glucose drink and the testing environment: pretreatment with 3.0 mg/kg PO of zolpidem was found to increase fluid consumption in rats that had received either 0 or 8 days pre-exposure to the testing conditions. Contrary to earlier reports, these results support the conclusion that zolpidem, like other benzodiazepine agonists, can directly modulate ingestive behaviour.

show abstract

Pyrazoloquinolines and zolpidem: Effects on hypertonic saline consumption in rehydrating rats

Cited by 16 publications

References 23 publications

The Pharmacology and Mechanism of Action of Zolpidem

The Pharmacology and Mechanism of Action of Zolpidem

Selective stimulation of central GABAAα2,3,5 receptors increases intake and motivation to consume sucrose solution in rats

Effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid consumption in the rat

Contact Info

Product

Resources

About