Pyrazoline as a medicinal scaffold

Abstract

Heterocyclic Chemistry is the backbone of medicinal compounds that exhibits numerous biological activities. Pyrazole and its derivatives possess nitrogen atom along with carbon atom as a substitution and show a diversity of biological activities such as antibacterial, antimicrobial, anti-inflammatory, antioxidant, antidiabetic, anticancer, antifungal, antidepressant, anticonvulsant, analgesic, and monoamine oxidases (MAOs)as shown by pyrazoline prepared from chalcone(Intermediate). The synthesized compounds are checked by the TLC and further analyzed by the IR, NMR, and UV spectroscopy.

One-pot synthesis, molecular docking, ADMET, and DFT studies of novel pyrazolines as promising SARS-CoV-2 main protease inhibitors

“…Nitrogen-containing heterocycles have a wide range of applications in medicine [ 12 , 13 , 14 ]. Therefore, the chemistry of pyrazoline compounds has attracted the attention of researchers due to their important biological activities such as anti-bacterial, anti-inflammatory, anti-cancer, anti-fungal, anti-oxidant, anti-depressant, anti-leishmanial, anti-convulsant, and anti-tumor properties [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], especially as anti-viral agent [ 24 , 25 , 26 , 27 ].…”