Pyrazolic tripods synthesis and cation binding properties

Malek, Fouad; Ramdani, Abdelkrim; Radi, Smaail

doi:10.3184/0308234042430458

Cited by 24 publications

(17 citation statements)

References 11 publications

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“…In our laboratory, a number of pyrazole based tripodal ligands have been studied . These ligands incorporating in their structures two sp 2 and sp 3 hybridized amine nitrogen atoms, could be distinguish according to their side arms and the nature of junctions (N–C–N or N–C–C) that bound the pyrazole ring to the lateral arm.…”

Section: Introductionmentioning

confidence: 99%

“…These ligands incorporating in their structures two sp 2 and sp 3 hybridized amine nitrogen atoms, could be distinguish according to their side arms and the nature of junctions (N–C–N or N–C–C) that bound the pyrazole ring to the lateral arm. Therefore, they were found in several fields such as catalysis, extraction of heavy metals and pharmacology . However, some studies have reported that such ligands present no antibacterial activities similarly to the thiophene tripods .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, Antimicrobial Activity, and Docking Studies of New Triazolic Tripodal Ligands

Harit

Bellaouchi

Rokni

et al. 2017

Chemistry & Biodiversity

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The synthesis and characterization of new N-donor bitriazolic tripods were reported. The in vitro antibacterial and antifungal activities of these products were screened against fungal strain (Candida pelliculosa) and against four bacterial strains (Micrococcus luteus, Bacillus subtilis, Listeria innocua, and Escherichia coli). Biological data revealed the effect of the chemical structure on antimicrobial activity. Molecular docking studies of some compounds showed that they could act as inhibitors for the biotin carboxylase enzyme.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antimicrobial Activity, and Docking Studies of New Triazolic Tripodal Ligands

Harit

Bellaouchi

Rokni

et al. 2017

Chemistry & Biodiversity

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“…In all the cases, we note that these two membranes present an interesting phenomenon of transport towards the transition metal cations compared with the previous membranes10–12 incorporating the mono‐ pyrazolic, the linear bi‐pyrazolic units and the bipyrazolic tripods. We recall here that the tetrapyrazolic tripods present higher complexation ability towards the transition metal cations compared with the mono‐ and bi‐pyrazolic ligands 4–6. We can thus say that the phenomenon of transport is governed by the complexation ability of ligands.…”

Section: Resultsmentioning

confidence: 87%

“…In our recent works, a series of acyclic pyrazole compounds containing one, two, three or four pyrazole rings were prepared and demonstrated to extract only the heavy metal cations,1–6 when the macrocyclic pyrazolic compounds expected to form stable complexes both with heavy and alkali metals 7–9…”

Section: Introductionmentioning

confidence: 99%

Transport abilities of new synthesised membrane materials incorporating tetrapyrazolic tripods

Malek

Radi

2008

J of Applied Polymer Sci

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The synthesis of new membrane materials was carried out by photopolymerisation of formulation that contain the active tetrapyrazolic tripods monomers spread on a polyacrylonitrile support. The obtained membrane films were applied for their facilitated transport and extraction power towards Cd(II), Pb(II), and Hg(II). We have determined both the diffusion flux F of different cations and the selectivity S of the prepared membranes towards each cations.

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“…[10][11][12][13][14][15][16][17][18] However, the present ligands 5-7 towards others metals. We can thus suggest an important selectivity for these ligands towards copper and lead.…”

Section: Liquid-liquid Extraction Of Individual Cationsmentioning

confidence: 93%

New Functionalised C,C-pyridylpyrazoles: Synthesis and Cation Binding Properties

Radi

Attayibat

Ramdani

et al. 2009

Journal of Chemical Research

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The synthesis of two new C,C-pyridylpyrazole isomers with a functionalised arm is described. The complexation capabilities of these ligands compared to their homologues towards bivalent metals (Hg 2+ , Cd 2+ , Pb 2+ , Cu 2+ , Zn 2+ ) and alkali metal ions (K + , Na + , Li + ) were investigated using a liquid-liquid extraction process. The percentage limits of extraction were determined by atomic absorption measurements.Chelating ligands based on the pyrazole ring have been described extensively in the literature 1-6 including several reviews. 7-9 In our recent work, a series of acyclic pyrazole compounds containing one, two, three or four pyrazole rings were prepared and demonstrated to extract only transition metal cations, 10-15 whereas macrocyclic pyrazolic compounds are expected to also form stable complexes with alkali metals. [16][17][18] This aptitude is mainly due to the presence of sp 2 hybrid nitrogen donors with the involvement of geometry and the nature of the ligands.Pyrazole-associated pyridine groups showed also the ability to complex transition metal ions. [19][20][21][22][23][24] However, complexation studies of pyridylpyrazole compounds are less well-known in the literature. It was therefore interesting to increase the diversity of pyridylpyrazole-based ligands with a view to study their complexation capabilities compared to ligands with pyrazoles units only.Here, we report the synthesis of two new C,C-pyridylpyrazole isomers 5 and 6 ( Fig. 1) with a donor heteroatom in a side chain. The complexation capabilities of these new functionalised C,C-pyridylpyrazole isomers 5 and 6 compared to their homologues such as unfunctionalised C,C-pyridylpyrazole 7, 23 C,N-pyridylpyrazole 8 24 and pyrazolylpyrazole 9 11 ligands were investigated using a liquid-liquid extraction process towards bivalent metal ions (Hg 2+ , Cd 2+ , Pb 2+ , Cu 2+ , Zn 2+ ) and alkaline metal ions (Li + , Na + , K + ). The relative capabilities of theses receptors in extracting theses cations were determined by the measurement of extracted cation percentage by atomic absorption.

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Pyrazolic tripods synthesis and cation binding properties

Cited by 24 publications

References 11 publications

Synthesis, Characterization, Antimicrobial Activity, and Docking Studies of New Triazolic Tripodal Ligands

Synthesis, Characterization, Antimicrobial Activity, and Docking Studies of New Triazolic Tripodal Ligands

Transport abilities of new synthesised membrane materials incorporating tetrapyrazolic tripods

New Functionalised C,C-pyridylpyrazoles: Synthesis and Cation Binding Properties

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