Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest

Dias, Luiza R.S.; Salvador, Raquel R.S.

doi:10.3390/ph5030317

Cited by 36 publications

(10 citation statements)

References 31 publications

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“…Antitumor, herbicides, antibacterial, antifungal, hypoglycemic, antidepressant, analgesic, anti-inflammatory, anti-cancer, enzyme inhibitor activity are shown among the pyrazoles. [1][2][3] As represented by the molecular formula, Pyrazole is a fivemembered ring structure consisting of three carbon atoms and two nitrogen atoms in adjacent positions. The word pyrazole was first coined by Ludwig Knorr in 1883.…”

Section: Pyrazolementioning

confidence: 99%

Chemistry and Pharmacological Activities of Pyrazole and Pyrazole Derivatives: A Review

Gurdeep¹,

Chandra²,

Sachan³

2020

IJPSRR

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At the heart of current research is the battle for more efficient and less toxic treatment approaches for diseases. Pyrazole and its derivatives have emerged as an influential scaffold that has drawn the attention of researchers in the field of medicinal chemistry due to its appreciable diversity in biological activities. Pyrazole derivatives have found numerous applications in fluorescent substances, dyes, and agrochemicals. Pyrazole is a multifunction lead compound for efficient biologically active molecules generated by researchers. They have shown a widespread biological and pharmacological activity such as antitumor, analgesic, antiinflammatory, antimicrobial, antitubercular, antileishmanial activity, ACE inhibitors, antidiabetic, antiparkinsonian and neuroprotective properties. This rational diversity in the pattern of physiological reaction has led many scientists, with far more successful pharmacological intervention, to refine and create new structural alternatives. This Review is important for previous studies and initiatives to explore in the near future the various activities of compounds associated with pyrazole and pyrazole derivatives.

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Section: Pyrazolementioning

confidence: 99%

Chemistry and Pharmacological Activities of Pyrazole and Pyrazole Derivatives: A Review

Gurdeep¹,

Chandra²,

Sachan³

2020

IJPSRR

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“…Commonly used anti-inflammatory drugs such as phenylbutazone, propyphenazone, SC558 and so forth, possess a pyrazole moiety as a functional part of the drug. The internalized carbohydrazide bonds in the pyrazolone moiety also play a role in anti-inflammatory activity [14]. The NSAIDs with high selectivity towards COX-2 might also act as anticancer agents [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

(Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one

Mohan¹,

Sarojini

Narayana

et al. 2018

Molbank

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The title compound (Z)-4-[2-(3,4-difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)one 4 was synthesized by the reaction of ethyl 2-[2-(3,4-difluorophenyl)hydrazono]-3-oxobutanoate 3 with hydrazine hydrate. The diazotization of 3,4-difluoroaniline, followed by the treatment with ethyl acetoacetate, afforded intermediate 3. The synthesized compound 4 was characterized by FTIR, 1 H-NMR, 13 C-NMR and LCMS, and it showed synergistic anti-inflammatory, antiproliferative and antibacterial activities.

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“…However, they were unable to complementing chagasic therapy (Wingeter et al 2007, Hidron et al 2010, Coura and Borges-Pereira 2012, Dias and Salvador 2012.…”

Section: Introductionmentioning

confidence: 99%

New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activity

Salvador

Bello

Barreto

et al. 2016

An. Acad. Bras. Ciênc.

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This paper reports the in vitro trypanocidal activity evaluation of new carbohydrazide derivatives from 3-methyl-1-phenyl-1H-pyrazolo [3,4-b]pyridine, substituted at C-6 position by phenyl, methyl or trifluoromethyl group. These compounds were evaluated in order to identify the antiparasitic profile against trypomastigote and amastigote forms of Trypanosoma cruzi. The 4-carbohydrazide derivatives presented different profiles of activity. In the investigation of the chemical structure influence in the trypanocidal activity, the results indicated there are large lipophilicity and volume differences among these derivatives. The complementarities of their stereoelectronic and physical-chemical aspects seem to be relevant for the biological activity against T. cruzi.

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Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest

Abstract: The main purpose of this paper is to provide an insight into the biological activities of pyrazole derivatives which contain the carbohydrazide moiety.

Cited by 36 publications

References 31 publications

Chemistry and Pharmacological Activities of Pyrazole and Pyrazole Derivatives: A Review

Chemistry and Pharmacological Activities of Pyrazole and Pyrazole Derivatives: A Review

(Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one

New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activity

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