Pyrazole-based compounds in chitosan liposomal emulsion for antimicrobial cotton fabrics

Nada, Ahmed A.; Al‐Moghazy, Marwa; Soliman, A. M.; Rashwan, Gehan M.T.; Eldawy, Taghreed Hosny Ahmed; Hassan, Ashraf Abd Elhakim; Sayed, G. H.

doi:10.1016/j.ijbiomac.2017.09.031

Cited by 43 publications

(29 citation statements)

References 21 publications

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“…Nada et al synthesized new series pyrazol-based derivatives and tested for their antimicrobial against bacterial strains E. coli and S. aureus . Data showed that pyrazole compound 204 was potent only at 0.075 mg/mL against the tested microorganisms [ 108 ]. A new series of pyrazole-containing s-triazine derivatives were synthesized by Sharma et al and investigated for antimicrobial and antifungal activity against the growth of several microorganisms.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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“…After the extraction, the hydrogels and extracts were separated. Subsequently, the extracts were added to the cells in quadruplicates ( n = 4) and incubated for 24 h. The amount of living cells was determined by the MTT assay …”

Section: Methodsmentioning

confidence: 99%

Stimuli-Free and Biocompatible Hydrogel via Hydrazone Chemistry: Synthesis, Characterization, and Bioassessment

et al. 2018

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Functionalization of starch with oxidative cleavage reaction to yield the corresponding dialdehyde derivatives has been employed as an approach for gel formation via Schiff's base reaction. However, this reaction is known as reversible and hydrolysable in aqueous solutions. In this study, the potential of hydrazone chemistry to be used in the synthesis of stimuli‐free and stable hydrogels is investigated. Soluble starch is selectively oxidized to give aldehydic‐starch with different aldehyde contents 39.9, 34.6, and 22.6 aldehyde group/100 anhydroglucose unit (AGU). Adipic dihydrazide was used as an α‐effect nucleophile to react with the dialdehyde starch and obtain stable hydrazone‐based and stimuli‐free hydrogels. Hydrazone chemistry of aldehydic‐starch and adipic dihydrazide (AD) is demonstrated by spectral analysis. As well, the biocompatibility with human skin fibroblasts cells is investigated using a cytotoxicity assay. SEM images show the pore sizes vary from 575 to 4752 nm related to AD concentrations. The swelling degree recorded an increase of 900%, 500%, and 600% at pH 4, pH 7, and pH 9, respectively. Hydrogels showed varied mechanical behavior as a function of AD concentrations.

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“…The padding bath generally contains a binder to promote adhesion of the finishing agent. The padding process requires good affinity with the textiles, and it may not be suitable for inert materials such as polyesters unless preliminary surface activation is performed [173,174,175]. Spray techniques are also used for textile finishing; they can be implemented in process line followed by fixation treatments.…”

Section: Bio-functional Textilesmentioning

confidence: 99%

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

et al. 2019

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In the field of pharmaceutical technology, significant attention has been paid on exploiting skin as a drug administration route. Considering the structural and chemical complexity of the skin barrier, many research works focused on developing an innovative way to enhance skin drug permeation. In this context, a new class of materials called bio-functional textiles has been developed. Such materials consist of the combination of advanced pharmaceutical carriers with textile materials. Therefore, they own the possibility of providing a wearable platform for continuous and controlled drug release. Notwithstanding the great potential of these materials, their large-scale application still faces some challenges. The present review provides a state-of-the-art perspective on the bio-functional textile technology analyzing the several issues involved. Firstly, the skin physiology, together with the dermatological delivery strategy, is keenly described in order to provide an overview of the problems tackled by bio-functional textiles technology. Secondly, an overview of the main dermatological nanocarriers is provided; thereafter the application of these nanomaterial to textiles is presented. Finally, the bio-functional textile technology is framed in the context of the different dermatological administration strategies; a comparative analysis that also considers how pharmaceutical regulation is conducted.

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Pyrazole-based compounds in chitosan liposomal emulsion for antimicrobial cotton fabrics

Cited by 43 publications

References 21 publications

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Stimuli-Free and Biocompatible Hydrogel via Hydrazone Chemistry: Synthesis, Characterization, and Bioassessment

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

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