Pyrazinamide-Induced Granulomatous Hepatitis

Knobel, B; Buyanowsky, George; Dan, Michael; Zaidel, Liliana

doi:10.1097/00004836-199706000-00019

Cited by 27 publications

(10 citation statements)

References 7 publications

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“…Acute dose-related hepatocellular necroses have also been reported [52]. Of note, allopurinol decreases the clearance of pyrazinamide and increases the risk for toxicity.…”

Section: Pyrazinamidementioning

confidence: 95%

Hepatotoxicity of Antibacterials: Pathomechanisms and Clinical Data

2010

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Drug-induced hepatotoxicity is a frequent cause of liver disease and acute liver failure, particularly in patients treated with multiple drugs. Several antibacterial drugs have the potential to cause severe liver injury and failure. This article aims to increase the awareness and understanding of drug induced liver injury (DILI) due to antibacterial drugs. It reviews the pattern of antibacterial DILI and provides details on molecular mechanisms and toxicogenomics, as well as clinical data based on epidemiology studies. Certain antibacterial drugs are more frequently linked to hepatotoxicity than others. Therefore, the hepatotoxic potential of tetracyclines,sulfonamides, tuberculostatic agents, macrolides, quinolones,and beta-lactams are discussed in more detail. Efforts to improve the early detection of DILI and the acquisition of high-quality epidemiological data are pivotal for increased patient safety.

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“…Acute dose-related hepatocellular necroses have also been reported [52]. Of note, allopurinol decreases the clearance of pyrazinamide and increases the risk for toxicity.…”

Section: Pyrazinamidementioning

confidence: 95%

Hepatotoxicity of Antibacterials: Pathomechanisms and Clinical Data

2010

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“…7 However, it must be appreciated that this may well be an underestimate, because patients with drug reactions characterized by nonspecific liver dysfunction following a short period of drug ingestion do not usually undergo liver biopsy. There have recently been reports of hepatic granulomas induced by drugs that had not previously been considered to be causal of this condition, 11,[16][17][18][19][20] and we therefore believe that many more drugs may potentially play a role in the development of hepatic granuloma.…”

Section: Discussionmentioning

confidence: 91%

Drug-induced hepatitis with hepatic granuloma due to saridon

et al. 2002

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A 38-year-old Japanese woman with no past history of liver disease developed liver dysfunction associated with fever, anorexia, and general malaise following the prolonged administration of saridon. A liver biopsy demonstrated multiple noncaseating epithelioid granulomas within hepatic lobules, with an inflammatory cell infiltrate of the lobular parenchyma and portal tracts. Viral markers and autoantibodies were negative. Lymphocyte stimulation tests for saridon and for isopropylantipyrine, one of the constituents of saridon, were positive, and therefore a diagnosis of drug-induced hepatitis due to administration of saridon was made. Her symptoms resolved and liver function test results returned to normal following discontinuation of the drug. The possibility of drug-induced hepatitis must be considered when liver dysfunction or systemic symptomatology develops during saridon therapy.

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“…Hepatic granulomas may also develop during Hodgkin’s disease or sometimes even precede lymphomas 10 . In addition, GH may be caused by a variety of drugs 11–15 …”

Section: Discussionmentioning

confidence: 99%

“…10 In addition, GH may be caused by a variety of drugs. [11][12][13][14][15] Sarcoidosis is an idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with none or little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones and parotid glands.…”

Section: Case Reportmentioning

confidence: 99%

Associated benign liver tumors in idiopathic granulomatous hepatitis: A case report

Grazi¹,

Vetrone²,

Ercolani³

et al. 2007

Hepatology Research

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We report a unique association of ruptured hepatocellular adenoma, focal nodular hyperplasia and granulomatous hepatitis in a young woman taking oral contraceptives. Diffuse granulomatous hepatitis was found in the liver parenchyma, which was associated with a large granulomatous mass of the left lobe and loco-regional granulomatous lymphadenitis. We cannot give a full explanation of the situation, which represented a challenge in the diagnosis and in the treatment of this patient.

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Pyrazinamide-Induced Granulomatous Hepatitis

Cited by 27 publications

References 7 publications

Hepatotoxicity of Antibacterials: Pathomechanisms and Clinical Data

Hepatotoxicity of Antibacterials: Pathomechanisms and Clinical Data

Drug-induced hepatitis with hepatic granuloma due to saridon

Associated benign liver tumors in idiopathic granulomatous hepatitis: A case report

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