pyramus and thisbe: FGF genes that pattern the mesoderm of <i>Drosophila</i> embryos

Stathopoulos, Angelike; Tam, Bergin; Ronshaugen, Matthew; Frasch, Manfred; Levine, Michael

doi:10.1101/gad.1166404

Cited by 168 publications

(218 citation statements)

References 49 publications

(67 reference statements)

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“…FGF signaling has been implicated in playing a role in coordinating gastrulation movements and the induction of mesoderm in both vertebrates (Isaacs et al 1994;Rossant et al 1997) and flies (Stathopoulos et al 2004). The onset of expression of NvSprouty, a likely target of FGF signaling (Nutt et al 2001;Sivak et al 2005), in the blastula (Fig.…”

Section: A Role For Fgfs In Gastrulation In Cnidariansmentioning

confidence: 98%

“…In mouse, FGF signaling through FGF-10 and FGFR2-IIIb direct branching morphogenesis of the lungs (Min et al 1998;Shishido et al 1997;Stathopoulos et al 2004), and although mammalian lungs and insect trachea may not be directly homologous, these data suggest a conserved role for FGF signaling in controlling branching morphogenesis in organisms as diverse as flies and mammals.…”

Section: Conserved Roles Of Fgf Signalingmentioning

confidence: 99%

“…In Drosophila, a second receptor (heartless) and pair of FGF ligands (pyramus and thisbe) coordinate gastrulation movements and mesoderm induction (Huang and Stern 2005;Stathopoulos et al 2004). Heartless is required for cell-autonomous spreading of mesodermal cells, as they migrate dorsolaterally under the neurogenic ectoderm, which expresses the FGF ligands pyramus and thisbe (Stathopoulos et al 2004).…”

Section: Conserved Roles Of Fgf Signalingmentioning

confidence: 99%

“…FGF signals often work in concert with other important pathways, such as transforming growth factor-β (TGF-β), Wnt, Hedgehog, and Notch (Gerhart 1999). In both invertebrates and vertebrates, FGF signaling functions in body plan patterning, including mesoderm and neural induction and coordinate cell movements during gastrulation (Bertrand et al 2003;De Robertis and Kuroda 2004;Isaacs et al 1994;Popovici et al 2005;Rossant et al 1997;Sheng et al 2003;Sivak et al 2005;Stathopoulos et al 2004). …”

Section: Introductionmentioning

confidence: 99%

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FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian

2007

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The fibroblast growth factor (FGF) signal transduction pathway serves as one of the key regulators of early metazoan development, displaying conserved roles in the specification of endodermal, mesodermal, and neural fates during vertebrate development. FGF signals also regulate gastrulation, in part, by triggering epithelial to mesenchymal transitions in embryos of both vertebrates and invertebrates. Thus, FGF signals coordinate gastrulation movements across many different phyla. To help understand the breadth of FGF signaling deployment across the animal kingdom, we have examined the presence and expression of genes encoding FGF pathway components in the anthozoan cnidarian Nematostella vectensis. We isolated three FGF ligands (NvFGF8A, NvFGF8B, and NvFGF1A), two FGF receptors (NvFGFRa and NvFGFRb), and two orthologs of vertebrate FGF responsive genes, Sprouty (NvSprouty), an inhibitor of FGF signaling, and Churchill (NvChurchill), a Zn finger transcription factor. We found these FGF ligands, receptors, and response gene expressed asymmetrically along the oral/aboral axis during gastrulation and in a developing chemosensory structure of planula stages known as the apical tuft. These results suggest a conserved role for FGF signaling molecules in coordinating both gastrulation and neural induction that predates the Cambrian explosion and the origins of the Bilateria.

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Section: A Role For Fgfs In Gastrulation In Cnidariansmentioning

confidence: 98%

Section: Conserved Roles Of Fgf Signalingmentioning

confidence: 99%

Section: Conserved Roles Of Fgf Signalingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian

2007

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“…While this paper was in press, two papers were published describing the identification of two novel genes encoding FGF-like growth factors in Drosophila, consistent with being ligands of HTL (Stathopoulos et al, 2004;Gryzik and Müller, 2004).…”

Section: Note Added In Proofmentioning

confidence: 99%

The RhoGEF Pebble is required for cell shape changes during cell migration triggered by theDrosophilaFGF receptor Heartless

et al. 2004

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The FGF receptor Heartless (HTL) is required for mesodermal cell migration in the Drosophila gastrula. We show that mesoderm cells undergo different phases of specific cell shape changes during mesoderm migration. During the migratory phase, the cells adhere to the basal surface of the ectoderm and exhibit extensive protrusive activity. HTL is required for the protrusive activity of the mesoderm cells. Moreover, the early phenotype of htl mutants suggests that HTL is required for the adhesion of mesoderm cells to the ectoderm.In a genetic screen we identified pebble (pbl) as a novel gene required for mesoderm migration. pbl encodes a guanyl nucleotide exchange factor (GEF) for RHO1 and is known as an essential regulator of cytokinesis. We show that the function of PBL in cell migration is independent of the function of PBL in cytokinesis. Although RHO1 acts as a substrate for PBL in cytokinesis, compromising RHO1 function in the mesoderm does not block cell migration. These data suggest that the function of PBL in cell migration might be mediated through a pathway distinct from RHO1. This idea is supported by allele-specific differences in the expressivity of the cytokinesis and cell migration phenotypes of different pbl mutants. We show that PBL is autonomously required in the mesoderm for cell migration. Like HTL, PBL is required for early cell shape changes during mesoderm migration. Expression of a constitutively active form of HTL is unable to rescue the early cellular defects in pbl mutants, suggesting that PBL is required for the ability of HTL to trigger these cell shape changes. These results provide evidence for a novel function of the Rho-GEF PBL in HTL-dependent mesodermal cell migration.

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Stripe formation in the early fly embryo: principles, models, and networks

Papatsenko

2009

BioEssays

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Early development of animal embryos begins from spatially distributed products of gene expression, i.e., gradients. While maternal and early zygotic genes form broad and/or terminal gradients, their direct targets appear later on as relatively narrow stripes, which foreshadow presumptive germ layers or future segments. Evidently, stripe expression of the zygotic genes is among the key mechanisms of embryo patterning. In this paper, known qualitative and quantitative models for the stripe formation are considered on the example of early embryogenesis of Drosophila. The current model analysis emphasizes the role of spatial information flow in development. Discussion is given on frequent network motifs, pointing to spatial stripe formation solutions.

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pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos

Cited by 168 publications

References 49 publications

FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian

FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian

The RhoGEF Pebble is required for cell shape changes during cell migration triggered by theDrosophilaFGF receptor Heartless

Stripe formation in the early fly embryo: principles, models, and networks

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