Pyramidotomy abolishes the abnormal movements evoked by intracortical microstimulation in adult rats that sustained neonatal cortical lesions

Corticospinal tract development and its plasticity after perinatal injury

“…The distribution of aberrant ipsilateral axons within the spinal grey matter resembles that of the contralateral corticospinal projection (Barth and Stanfield, 1990;McClung and Castro, 1975) and synaptic contacts have been demonstrated (Leong, 1976;McClung and Castro, 1975). Ipsilateral forelimb movements are observed following stimulation of the intact cortex at abnormally low current thresholds, which are abolished by medullary pyramidotomy (Kartje-Tillotson et al, 1985, 1987.…”

Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis

“…The size and organization of the "motor map" is altered in response to, and is thus indicative of, cortical injury (Gharbawie et al, 2005;Nudo, 1997;Williams et al, 2006), corticofugal fiber function (Kartje-Tillotson et al, 1987), and motor experience/learning (Adkins et al, 2006;Jacobs and Donoghue, 1991;Kleim et al, 1998Kleim et al, , 2002. Changes in ICMS motor map organization are also often used as a measure of peri-infarct tissue function after focal cortical stroke (Gharbawie et al, 2005).…”

Constraint-Induced Movement Therapy in the Adult Rat after Unilateral Corticospinal Tract Injury

“…The reticulospinal system is left intact in our lesion paradigm and might also contribute to the training effect. Nevertheless, control of precision movements, in particular of hand/forepaw, is a major function of the motor CST (Castro, 1972;Kalil and Schneider, 1975), and the contribution of uninjured CST fibers on behavioral improvements has been shown in previous studies (Kartje-Tillotson et al, 1987;Thallmair et al, 1998).…”