Pyostomatitis vegetans. A reactive mucosal marker for inflammatory disease of the gut

Pyodermatitis-Pyostomatitis Vegetans Associated with Ulcerative Colitis: Successful Treatment with Total Colectomy and Topical Tacrolimus

“…In a few cases with PD-PSV related to UC, complete remission was obtained after total colectomy [9,10] . Treatment with topical or systemic corticosteroids for PD-PSV has been beneficial in some patients [2,6,11] . Other treatments include systemic corticosteroids with dapsone [9] , azathioprine [12,13] , cy-…”

Pyostomatitis vegetans in childhood

“…Lesions show predilection for the gingival, labial and buccal mucosae, tonsillar region, and hard palate [6,8,26]. The pustules m a y coalesce to form large erosions or a snail track appearance [5,7].…”

“…Lesions show hyperkeratosis and acanthosis [4,26]. A dense cellular infiltrate is present t h r o u g h o u t the lamina propria and epithelium composed o f neutrophils and eosinophils which aggregate to form small abscesses leading to necrosis and ulceration [3,7,26].…”

“…Lesions show hyperkeratosis and acanthosis [4,26]. A dense cellular infiltrate is present t h r o u g h o u t the lamina propria and epithelium composed o f neutrophils and eosinophils which aggregate to form small abscesses leading to necrosis and ulceration [3,7,26]. The underlying connective tissue appears infiltrated with a dense population of lymphocytes, plasma cells, and eosinophils [4,6,20].…”

“…The term PV was first used in 1949 by McCarthy and Shklar [17], who focused attention on the oral lesions and believed that they represented the oral counterpart of pyoderma vegetans, which are unusual pustular and vegetative skin lesions located at the flexural regions [26] and has intra-epithelial abscesses with an eosinophilic infiltration on histopathological examination.…”