Pyogranulomatous dermatitis and panniculitis due to Nocardia nova in a cat

Blume, Guilherme Reis; Martins, Christine Souza; Matter, Letícia Beatriz; Vargas, Águeda Castagna de; Oliveira, Letícia Batelli de; Reis, Janildo Ludolf; Sant’Ana, Fabiano José Ferreira de

doi:10.1590/0103-8478cr20150254

Cited by 3 publications

(5 citation statements)

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“…Durante o tratamento, o animal passou pelo uso da clindamicina, depois amoxicilina associada a clavulanato de potássio e por fim foi utilizado até doxiciclina, no entanto não foram eficazes. Blume et al (2015) também relata a ineficacia da amoxilina associada ao clavulanato de potássio em um felino que apresentava lesões na região torácica, tendo sido realizado tratamento cirúrgico para conseguir a resolução do caso. No entanto, no presente trabalho, mesmo após a realização do tratamento cirúrgico, não foi obtido sucesso, provavelmente decorrente do quadro avançado da doença, do baixo estado nutricional e da possibilidade do animal apresentar alguma comorbidade que causasse imunossupressão.…”

Section: Discussionunclassified

Nocardiose em um Felino : Relato de caso

Reis¹,

Fontes²,

Oliveira³

et al. 2022

Pubvet

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A nocardiose é uma doença infecciosa que pode ocorrer de forma aguda ou crônica com características piogranulomatosas, podendo acometer o animal de forma sistêmica, sendo considerada rara em felinos. A infecção ocorre através do contato de feridas com o agente Nocardia spp. que se encontra em solo, água, madeira e outros locais favoráveis ao seu crescimento e contaminação. A doença pode gerar formação de fístulas, abscessos de forma localizada ou disseminada e apresentar secreção serossanguinolenta. Assim, o objetivo desse artigo é relatar um caso de nocardiose em um felino. O animal foi atendido em uma clínica veterinária privada de Lagarto/SE, tinha 3 anos de idade, sem raça definida (SRD), apresentando abscessos na região rostral, no abdômen, nos membros torácicos e membros pélvicos. O exame histopatológico diagnosticou nocardiose e o animal passou por tratamento farmacológico juntamente com cirurgia reconstrutiva. No entanto, o paciente foi a óbito apresentando ascite, anorexia e do baixo estado nutricional quando retornou à clínica. O tutor não autorizou a necropsia para elucidar a causa do óbito.

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Section: Discussionunclassified

Nocardiose em um Felino : Relato de caso

Reis¹,

Fontes²,

Oliveira³

et al. 2022

Pubvet

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“…A reação inflamatória encontrada em todos os casos foi sugestiva de infecção por Nocardia sp. A lesão histopatológica caracterizada pela presença de inflamação piogranulomatosa com predomínio de macrófagos epitelioides formando pseudorosetas associado a grande quantidade de neutrófilos e necrose central também é frequentemente relatada [2,6,10]. Esse padrão de resposta inflamatória piogranulomatosa é geralmente característica de infecções por actinomicetos, já que esta resposta celular tem como objetivo circundar os agentes resistentes e impedir a sua disseminação [16].…”

Section: Discussionunclassified

“…e Streptococcus spp. [2,9], doenças fúngicas como o micetomas eumicóticos, pseudomicetoma dermatofítico [9], criptococose [8], pitiose [18] e as neoplasias [9].…”

Section: Discussionunclassified

Nocardiosis in Cats - Clinical, Anatomopathological and Morphotintorial Characteristics

Firmino

Frade

Nascimento

et al. 2021

Acta Scientiae. Vet.

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Background: Nocardiosis is an infectious bacterial disease that can cause cutaneous/ subcutaneous, pulmonary and systemic lesions in different species of domestic animals. The type of transmission occurs through mechanical lesions on the skin or contamination of wounds, in cases of skin involvement, inhalation of aerosols and ingestion of contaminated materials are involved in the pathogenesis of the respiratory and digestive form of the disease. This paper described 4 cases of nocardiosis in cats, addressing the clinical, anatomopathological and morphotintorial characteristics of Nocardia sp.Cases: Four cases of nocardiosis in cats were reviewed, in which data related to breed, sex, age, origin, clinical signs, macroscopic and histological lesions described in necropsy protocols were evaluated. The histological tissue sections stained with Hematoxylin and Eosin (HE) were evaluated in order to characterize the inflammatory response in each case. In addition, paraffin blocks of fragments from affected organ were selected to perform special histochemical staining techniques of Grocott Methenamine Silver (GMS), modified Ziehl-Neelsen, Gram Brown-Brenn and Giemsa stain which are the most characterized techniques used for histopathological diagnoses and it was also used an immunohistochemical test with polyclonal antibody anti-Nocardia sp. (non-commercial). The animals were adults of both sexes, mixed breed, not castrated and semi-domesticated. Neither immunosuppressive factors nor concomitant diseases were identified in the cases studied. The main clinical signs were apathy, anorexia, dehydration, phlegmon and draining tracts. Macroscopically, skin / subcutaneous tissue (3/4), skeletal muscle (2/4), lymph nodes (2/4), liver (2/4), omentum (1/4), spleen (1/4) were affected. In addition, it could be noted that mandibular bone (1/4), pleural tissue (1/4), left testicle (1/4) and Central Nervous System (CNS) (1/4) were also affected by this disease. Microscopically, regarding all cases, there was a pyogranulomatous inflammation in the affected organs. With respect to cases 1, 3 and 4, filamentous, branched, slightly basophilic structures in loose or individual aggregates in the interior of the pseudo-rosettes and in the necrotic areas were observed in the HE-stained tissue sections. In all cases submitted to special histochemical techniques, filamentous, branched, individual or loose aggregate structures were observed, the samples were impregnated with silver, and bacteria appear as blue using the Brown-Brenn Gram technique, and stained red in the modified Ziehl-Neelsen, and stained faintly pink in Giemsa stain. The bacteria were observed mainly in the border of the pyogranulomas, in the center of the pseudo-rosettes and in the necrotic areas, being compatible with the infection by Nocardia sp. All cases were positive for immunohistochemistry (IHC).Discussion: Nocardiosis was diagnosed in all cats in this study based on the anatomopathological findings associated with the visualization of the agent and its morphotintorial characteristics by using special histochemical stains and being confirmed by IHC. It occurs mainly in the cutaneous and/or subcutaneous tissues, with systemic involvement and death of the affected animals, in addition to affecting bone tissue considered an uncommon site for the disease. The diagnosis can be established based on the anatomopathological findings associated with the morphotintorial characteristics by using special histochemical stains, which are important for evidencing and morphologically characterizing the agent, as well as being confirmed by IHC.Keywords: disease in cat, pyogranulomatous inflammation, Nocardia sp.Título: Nocardiose em gatos - achados clínicos, anatomopatológicos e morfotintoriais Descritores: doença de gato, inflamação piogranulomatosa, Nocardia sp.

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“…115 Infection in the inguinal region may be extensive and mimic rapid-growing mycobacterial panniculitis. 112,121…”

Section: Bacteria – and Associated Cutaneous Diseasementioning

confidence: 99%

“…115 Infection in the inguinal region may be extensive and mimic rapid-growing mycobacterial panniculitis. 112,121 Diagnosis is often made through a combination of cytologic, histologic and microbiologic techniques. Filamentous bacteria may be identified on cytologic samples (Figure 4b).…”

Section: S U L F U R G R a N U L E Smentioning

confidence: 99%

Skin as a marker of general feline health: Cutaneous manifestations of infectious disease

Backel

Cain

2017

Journal of Feline Medicine and Surgery

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This review is aimed at veterinarians who treat cats and especially those with an interest in feline dermatology. Tables are included to allow the reader to formulate a concise list of differential diagnoses for clinically similar presentations. The diagnostic approach to a case of ulcerative facial dermatitis is reviewed in a Case Notes quiz. Evidence base: This article includes up-to-date information regarding dermatologic manifestations of less commonly encountered feline cutaneous infectious diseases. Information has been drawn from the published, peer-reviewed literature and the most recent textbook chapters with a particular aim of describing and differentiating clinical lesions and the diagnostic approach to cutaneous disease, especially in unusual cases.

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Pyogranulomatous dermatitis and panniculitis due to Nocardia nova in a cat

Abstract: This report describes the clinical, pathological and microbiological findings of an uncommon infection in a cat by

Cited by 3 publications

References 7 publications

Nocardiose em um Felino : Relato de caso

Nocardiose em um Felino : Relato de caso

Nocardiosis in Cats - Clinical, Anatomopathological and Morphotintorial Characteristics

Skin as a marker of general feline health: Cutaneous manifestations of infectious disease

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