Pyogenic Prostatitis: A Clinical Analysis of the Immune Response

Cumming, Robert E.; Chittenden, George E.

doi:10.1016/s0022-5347(17)71843-5

Cited by 7 publications

(1 citation statement)

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“…(1995). Before the introduction of penicillin, prostatic abscesses were a known complication of gonorrhoea (Kretschmer, 1921; Weinberger et al ., 1988), and gonococci were associated with chronic prostatitis (Cumming and Chittenden, 1938). The human eye is yet another site of primary gonococcal infection, particularly in the newborn (Laga et al ., 1989; Lewis et al ., 1990), and the human corneal epithelium was reported by Gupta et al .…”

Section: Discussionmentioning

confidence: 99%

Galectin-3 binds lactosaminylated lipooligosaccharides fromNeisseria gonorrhoeaeand is selectively expressed by mucosal epithelial cells that are infected

John

Jarvis

Swanson

et al. 2002

Cellular Microbiology

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b -galactoside. Galectin-3 had the highest affinity for the nLc 6 LOS, which is made by a strain that is highly infectious for the male urethra, but also bound nLc 4 LOS and to a Lac LOS. The lacto-N -neotetraose tetrasaccharide was a more potent inhibitor of galectin-3 binding to LOS than either lactose or N -acetyllactosamine. The relative affinity of galectin-3 for gonococci mirrored its affinity for purified LOS. Western blot analysis revealed expression of galectin-3 by human endometrial adenocarcinoma and prostatic epithelial cells that can be invaded by gonococci. Immunohistochemistry of human fallopian tube epithelium showed localized expression of galectin-3 by non-ciliated cells, the specific cell gonococci invade in this tissue. We conclude that because of its location and affinity for gonococcal LOS galectin-3 could play a role in gonococcal infection.

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