Pyogenic liver abscesses: mortality-related factors

Ruiz-Hernández, J.J.; León-Mazorra, Magdalena; Conde-Martel, Alicia; Marchena‐Gómez, Joaquín; Hemmersbach‐Miller, Marion; Betancor-León, Pedro

doi:10.1097/meg.0b013e3282eeb53b

Cited by 80 publications

(76 citation statements)

References 17 publications

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“…Several studies to identify prognostic factors for case fatality in PLA patients have been performed, yet discrepancies exist regarding this issue [3,4,7,[9][10][11]29]. No other studies identifying prognostic factors for old PLA patients have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…With the advances in diagnostic techniques and therapeutic modalities, the incidence of PLA has increased and the case-fatality rate has gradually declined, but remains within the range of 6-35% [2][3][4][5][6][7][8][9][10][11]. Further, the mean age of PLA patients has increased since 1938 and PLA has become a disease of the middle-aged and elderly with a reported mean age S.-C. Chen et al…”

Section: Introductionmentioning

confidence: 99%

“…of 47-65 years [2][3][4][5][6][7][8][9][10][11]. This change in patient demographics likely reflects a change in the predominant aetiology.…”

Section: Introductionmentioning

confidence: 99%

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Pyogenic liver abscess in the elderly: clinical features, outcomes and prognostic factors

et al. 2008

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Background: pyogenic liver abscess (PLA) is a potentially life-threatening disease in middle-to-old aged persons. Objective: to compare the differences in clinical features and outcomes between older and younger PLA patients, and to identify predictors of outcomes in older patients. Design: retrospective chart review of all PLA patients between July 1999 and June 2007. Setting: a 1,600-bed primary and tertiary care centre. Subjects: in total, 339 patients were enrolled and included 118 ≥65 years of age (the elderly group) and 221 patients <65 years of age (the non-elderly group). Methods: clinical features, laboratory, imaging and microbiologic findings, treatment and outcomes for each of the included patients were collected. The predictor of outcome was determined using logistic regression and purposeful selection of covariates. Results: the elderly group had a higher APACHE II score on admission, a biliary abnormality, a malignancy, a pleural effusion, polymicrobial, anaerobic or multi-drug-resistant isolates, inappropriate initial antibiotics, a longer hospitalisation and a longer parenteral antibiotic treatment period than the non-elderly group, whereas the non-elderly group was more likely to be alcoholic men with cryptogenic origin of abscess and Klebsiella pneumoniae infection. There was no difference in case fatality between the elderly (13.6%) and non-elderly (8.6%) groups despite the elderly group having a poorer host status on admission. In multivariate analysis, age (P = 0.028) and APACHE II score at admission ≥15 (P = 0.001) were risk factors, but K. pneumoniae infection (P = 0.012) was a protective factor for fatality in older PLA patients. Conclusions: these data suggest that older PLA patients wound have a fair outcome compared to younger patients, but require longer hospitalisations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pyogenic liver abscess in the elderly: clinical features, outcomes and prognostic factors

et al. 2008

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“…In addition, the epidemiology has changed dramatically in recent years, with the annual increases in incidence being 5.6% and 6.4% in the United States and Taiwan, respectively. The overall mortality rates of PLA remain high, ranging from 2.5% to 19%, 2–4,6,7 and the mortality rate in Taiwan is approximately 8.3%. 8 Recently, PLA has been associated with an increased risk of malignancy, 9–11 subsequent infections, 12–15 acute pancreatitis, 16 and stroke.…”

Section: Introductionmentioning

confidence: 99%

Pyogenic Liver Abscess is Associated With Increased Risk of Acute Kidney Injury

Sung

Lin

et al. 2016

Medicine

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“…[1][2][3][4][5] Underlying malignancy, besides diabetes mellitus and biliary tract disorders, is a common coexisting disease among PLA patients and accounts for 5% to 42% of these patients in various countries. 1,2,[6][7][8][9][10][11][12][13][14] In the literature, concomitant malignancy unlike other underlying disorders has been found to be a risk factor for PLA mortality.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes and Prognostic Factors of Cancer Patients with Pyogenic Liver Abscess

Chen

Lee

Tsai

et al. 2011

Journal of Gastrointestinal Surgery

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Pyogenic liver abscesses: mortality-related factors

Abstract: Mortality associated with PLA is high. The main risk factor for mortality is the development of sepsis and/or septic shock.

Cited by 80 publications

References 17 publications

Pyogenic liver abscess in the elderly: clinical features, outcomes and prognostic factors

Pyogenic liver abscess in the elderly: clinical features, outcomes and prognostic factors

Pyogenic Liver Abscess is Associated With Increased Risk of Acute Kidney Injury

Clinical Outcomes and Prognostic Factors of Cancer Patients with Pyogenic Liver Abscess

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