Pyogenic Liver Abscess and Papillon-Lefèvre Syndrome: Not a Rare Association

Almuneef, Maha; Khenaizan, Sultan Al; Ajaji, Sulaiman Al; Alanazi, Abdullah T

doi:10.1542/peds.111.1.e85

Cited by 87 publications

(67 citation statements)

References 30 publications

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“…Patients with PLS are prone to dental and liver abscess (4,5). The most common organisms associated with dental and liver infections are anaerobic bacteria (such as Actinobacillus actinomycetem comitans) and Staphylococcus aureus (5,6). In this study, the patient had a history of pyogenic liver abscess, preseptal cellulitis and loss of many teeth secondary to dental infections, and hyperkeratosis of the palms and soles.…”

Section: Dear Editormentioning

confidence: 82%

“…Infection caused by Citrobacter can be seen in many different forms, and is occasionally associated with abscess formation. Patients with PLS are prone to dental and liver abscess (4,5). The most common organisms associated with dental and liver infections are anaerobic bacteria (such as Actinobacillus actinomycetem comitans) and Staphylococcus aureus (5,6).…”

Section: Dear Editormentioning

confidence: 99%

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Severe Cutaneous Infection in a 7.5 Year-Old Boy with Papillon-Lefevre Syndrome

2016

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Section: Dear Editormentioning

confidence: 82%

Section: Dear Editormentioning

confidence: 99%

Severe Cutaneous Infection in a 7.5 Year-Old Boy with Papillon-Lefevre Syndrome

2016

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“…In addition to palmoplantar keratoderma and early periodontal destruction of primary and permanent dentition, other features may be associated with PLS, i.e., increased susceptibility to infection [16], increased risk of pyogenic liver abscess [40][41][42][43], calcification of the falx cerebri of the dura mater [44], excessive sweating (hyperhidrosis), and growth of fine body hair with the development of dirty-colored skin on the affected areas [45]. Recently, the first case of multiple brain abscesses in a child with PLS was reported [46].…”

Section: Secondary Features Associated With Plsmentioning

confidence: 99%

Syndromes That Include Both Palmoplantar Keratoderma And Severe Periodontitis: A Review

Dababneh¹

2013

Dentistry

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Palmoplantar keratodermas (PPK) include a heterogeneous group of disorders with overlapping clinical features. The main aspect of PPK is thickening and hyperkeratosis of the palmar and plantar skin, that may be hereditary or acquired; diffuse, focal, or punctuate; and transgrediens or progrediens. PPKs are further distinguished by their mode of inheritance and by the presence of certain associated clinical features. Periodontitis was reported in association with more than one syndrome characterized by PPK. An extensively reported one is the Papillon-Lefévre syndrome (PLS) which is characterized by early onset of PPK and periodontitis affecting the primary and secondary dentitions. In addition to PLS, Haim-Munk, HOPP, Variant Carvajal and Weary-Kindler are other syndromes manifested by PPK and reported in association with severe periodontitis. Atypical cases of PLS were also reported, such as partial expression or a late presentation of the syndrome. The aim of this article is to critically review the literature concerned with Papillon-Lefévre syndrome in its typical and atypical clinical presentation, in addition to other syndromes manifested at the same time by PPK and severe periodontitis.Thorough history and medical examination, together with periodontal, dermatologic, and genetic counseling, are important to exclude other existing medical conditions or other syndromes that might need special attention and care.

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“…Pyogeneic liver abscesses are a well recognized complication of neutrophil dysfunction in PLS (33). Four genes (CTSC, DPYS, GALK2 and PTER) were found to be actively expressed in human liver using BioGPS (34).…”

Section: Ten Genes Are Associated With Liver Diseasementioning

confidence: 99%

Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT

Kim¹,

Cho²,

Jun³

et al. 2010

BMB Reports

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Biochemical tests such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are useful for diagnosing patients with liver disease. In this study, we tested the association between copy number variation and the hepatic biomarkers AST and ALT based on 8,842 samples from population-based cohorts in Korea. We used Affymetrix Genome-Wide Human 5.0 arrays and identified 10,534 CNVs using HelixTree software. Of the CNVs tested using univariate linear regression, 100 CNVs were significant for AST and 16 were significant for ALT (P ＜ 0.05). We identified 39 genes located within the CNV regions. DKK1 and HS3ST3B1 were shown to play roles in heparan sulfate biosynthesis and the Wnt signaling pathway, respectively. NAF1 and NPY1R were associated with glycoprotein processes and neuropeptide Y receptor activity based on GO categories. PTER, SOX14 and TM7SF4 were expressed in liver. DPYS and CTSC were found to be associated with dihydropyrimidinuria and Papillon-Lefèvre syndrome phenotypes using OMIM. NPY5R was found to be associated with dyslipidemia using the Genetic Association Database. [BMB reports 2010; 43(8): 547-553]

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Pyogenic Liver Abscess and Papillon-Lefèvre Syndrome: Not a Rare Association

Cited by 87 publications

References 30 publications

Severe Cutaneous Infection in a 7.5 Year-Old Boy with Papillon-Lefevre Syndrome

Severe Cutaneous Infection in a 7.5 Year-Old Boy with Papillon-Lefevre Syndrome

Syndromes That Include Both Palmoplantar Keratoderma And Severe Periodontitis: A Review

Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT

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