“…The etiology of PG is not well understood, but some factors have been accused of being predisposing factors for this disease. They include trauma, traumalike activities (nose piercing, smallpox vaccination), chronic irritation, increased levels of female sex hormones, infections, viral oncogenes, retinoid therapy, and burn (1–4). Angiogenic factors, such as vascular endothelial and basic fibroblast growth factors, are believed to lead to the evolution of such tumors.…”