Pyodermatitis-Pyostomatitis Vegetans Associated with Crohn's Disease

Pyodermatitis vegetans responding to rifampicin and clindamycin

“…PDV is a rare inflammatory neutrophilic dermatosis that was initially described in 1898 by Hallopeau 7 . Previous reports have indicated that PDV is frequently associated with IBD in 70% of cases, and up to 100% in a recent cohort study 1, 2, 3, 4 , 6 , 8 . PDV commonly affects adults in the third decade of life with a male/female ratio of 3:1 3 , 9 .…”

“…The etiology of PDV is still unknown. However, variable immunologic and microbial factors have been proposed 8 …”

Pyodermatitis-Pyostomatitis Vegetans: A Cutaneous Clue for Crohn’s Disease

“…Often the clinical courses of PPV and IBD are parallel [1], and successful management of the underlying IBD typically results in resolution of PPV [2]. However, there have also been cases in which PPV develops and persists despite well controlled IBD [1,3,4]. Our patient was started on vedolizumab initially for Crohn's disease due to preference over infliximab, however he was eventually switched to infliximab after his skin manifestations continued to flare.…”

“…Often the clinical courses of PPV and IBD are parallel [1], and successful management of the underlying IBD typically results in resolution of PPV [2]. However, there have also been cases in which PPV develops and persists despite well controlled IBD [1,3,4].…”

“…Pyodermatitis-pyostomatitis vegetans (PPV) is a neutrophilic dermatosis characteristically associated with underlying inflammatory bowel syndrome (IBD) [1]. The first reported case of PPV was in 1898 by Francois Hallopeau [2], and only 37 cases of PPV were reported in the literature between 1979 and 2011 [3].…”