Pyodermatitis-pyostomatitis vegetans: a case report and review of literature

Gheisari, Mehdi; Zerehpoosh, Farahnaz Bidari; Zaresharifi, Shirin

doi:10.5070/d3265048779

Cited by 7 publications

(4 citation statements)

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“…The ﬁrst reports of PV were documented by Hallopeau in 1898, who described two cases with unusual pustular dermatosis and oral lesions that he called pyodermite vegetante 4. The term PV was later described by McCarthy in 1949, who believed that it was a variant of pyodermite vegetante, and since then 78 cases have been published in the literature 5–9…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of pyostomatitis vegetans and its management

O'Gorman,

Smyth,

Willis

2023

BMJ Case Rep

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A man in his early 50s was referred to the oral medicine clinic regarding a 6-month history of ulceration affecting the palate and gingivae. Intra-oral examination revealed multiple friable pustules on a background of erythema affecting the gingival sulci and ‘snail-track’ like ulceration affecting the palate. Histopathological analysis of the gingivae revealed features in keeping with a diagnosis of pyostomatitis vegetans (PV). Although he did not report any gastrointestinal symptoms, the patient was referred to gastroenterology and underwent colonoscopy and small bowel series examination. Colonic biopsies showed no features to suggest a diagnosis of inflammatory bowel disease (IBD). In 11 years since diagnosis of PV, the patient still shows no signs or symptoms suggestive of IBD. This case highlights a rare occurrence of PV without IBD, but emphasises the importance of appropriate referral to relevant medical specialities based on clinical and histopathological findings.

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Section: Discussionmentioning

confidence: 99%

Unusual presentation of pyostomatitis vegetans and its management

O'Gorman,

Smyth,

Willis

2023

BMJ Case Rep

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“…Pemphigus, especially pemphigus vegetans and IgA pemphigus, is also an important disease with shared pathogenesis with pyodermatitis pyostomatitis vegetans, because immunofluorescence examination can detect IgA or C3 deposition 1,3 or serum antibodies against BP180 or BP230 can be sometimes detected 26–28 . There are two types of pemphigus vegetans; Neumann type and Hallopeau type.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…Pyodermatitis pyostomatitis vegetans is a rare inflammatory mucocutaneous condition, involving the scalp, face, axilla, umbilicus and oral cavity 1–3 . Histopathologically, epidermal hyperplasia, focal acantholysis and dense inflammatory infiltrates with intraepidermal and subepidermal eosinophilic microabscesses can occur.…”

Section: Introductionmentioning

confidence: 99%

“…

Pyodermatitis pyostomatitis vegetans is a rare inflammatory mucocutaneous condition, involving the scalp, face, axilla, umbilicus and oral cavity. [1][2][3] Histopathologically, epidermal hyperplasia, focal acantholysis and dense inflammatory infiltrates with intraepidermal and subepidermal eosinophilic microabscesses can occur. There are several similarities between pyodermatitis pyostomatitis vegetans and other autoinflammatory neutrophilic or autoimmune bullous diseases; therefore, the diagnosis is sometimes difficult.

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confidence: 99%

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Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans

Yamamoto

2023

Experimental Dermatology

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Pyodermatitis pyostomatitis vegetans is a rare inflammatory condition, affecting the skin and/or mucous membrane. Some cases include both skin and mucous involvement, whereas others develop either skin or mucous lesions only. The typically affected areas are the scalp, face, trunk and extremities, including the flexural areas and umbilicus. Clinical features show erosive granulomatous plaques, keratotic plaques with overlying crusts and pustular lesions. Among mucous lesions, oral mucosa is most frequently involved, and gingival erythema, shallow erosions, cobblestone‐like papules on the buccal mucosa or upper hard palate of the oral cavity are also observed. Some of the lesions assume a ‘snail track’ appearance. Although there are several similarities between pyodermatitis pyostomatitis vegetans and other diseases, that is pyoderma gangrenosum, pemphigus vegetans and pemphigoid vegetans, the histopathological features of pyodermatitis pyostomatitis vegetans are unique in that epidermal hyperplasia, focal acantholysis and dense inflammatory infiltrates with intraepidermal and subepidermal eosinophilic microabscesses are observed. Direct immunofluorescence findings are principally negative. Activated neutrophils are supposed to play an important role in the pathogenesis of pyodermatitis pyostomatitis vegetans. The expression of IL‐36 and neutrophil extracellular traps (NETs) was observed in the lesional skin, and additionally, eosinophil extracellular traps (EETs) was detected in pyodermatitis pyostomatitis vegetans. A possible pathogenic role of NETs and EETs in the innate immunity and autoinflammatory aspects of pyodermatitis pyostomatitis vegetans was discussed.

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Bacterial Infections

Wootton,

Elliott

2024

Rook's Textbook of Dermatology

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The skin provides a barrier between the body and the external environment and it is colonised by the bacteria and other microorganisms that make up the skin microbiome. Bacterial infections occur when bacteria invade through damage to the skin barrier, via trauma or pre‐existing skin conditions, or through inoculation or inhalation; bacterial skin infections can range from minor irritations to life‐threatening conditions. This chapter explores bacterial infections which can affect the skin, from the common to the rare, describing the epidemiology, presentation and management of each condition.

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Pyodermatitis-pyostomatitis vegetans: a case report and review of literature

Cited by 7 publications

References 0 publications

Unusual presentation of pyostomatitis vegetans and its management

Unusual presentation of pyostomatitis vegetans and its management

Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans

Bacterial Infections

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