Pyodermatitis-pyostomatitis vegetans

Nayak, Surajit; Patro, Sibasish

doi:10.4103/ijd.ijd_59_16

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…“Pyostomatitis vegetans” is the mucosal counterpart of “pyodermatitis vegetans”, and mainly involves the oral cavity. The typical presentation includes multiple small pustules with a characteristic “snail track-appearance” [ 62 , 63 ]. Coexistence of skin and mucosal lesions is possible.…”

Section: Classificationmentioning

confidence: 99%

Dermatological Manifestations in Inflammatory Bowel Diseases

Antonelli

Bassotti

Tramontana

et al. 2021

JCM

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Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature on the dermatologic manifestations occurring in patients with inflammatory bowel diseases has been reviewed. The following dermatological manifestations associated with IBDs have been identified: (i) specific manifestations with the same histological features of the underlying IBD (occurring only in Crohn’s disease); (ii) cutaneous disorders associated with IBDs (such as aphthous stomatitis, erythema nodosum, psoriasis, epidermolysis bullosa acquisita); (iii) reactive mucocutaneous manifestations of IBDs (such as pyoderma gangrenosum, Sweet’s syndrome, bowel-associated dermatosis-arthritis syndrome, aseptic abscess ulcers, pyodermatitis–pyostomatitis vegetans, etc.); (iv) mucocutaneous conditions secondary to treatment (including injection site reactions, infusion reactions, paradoxical reactions, eczematous and psoriasis-like reactions, cutaneous infections, and cutaneous malignancies); (v) manifestations due to nutritional malabsorption (such as stomatitis, glossitis, angular cheilitis, pellagra, scurvy, purpura, acrodermatitis enteropathica, phrynoderma, seborrheic-type dermatitis, hair and nail abnormalities). An accurate dermatological examination is essential in all IBD patients, especially in candidates to biologic therapies, in whom drug-induced cutaneous reactions may assume marked clinical relevance.

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Section: Classificationmentioning

confidence: 99%

Dermatological Manifestations in Inflammatory Bowel Diseases

Antonelli

Bassotti

Tramontana

et al. 2021

JCM

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“…The main differential diagnosis of pemphigus vegetans in its vulvar localization is pyodermatitis-pyostomatitis vegetans, with which it presents several clinical and histological similarities. 5 Direct immunofluorescence, which shows IgG and C3 deposits in the epidermis, and indirect immunofluorescence, which detects antibodies directed against intercellular substances, allow differentiation between these two entities. 5 Treatment with oral steroids alone does not always lead to remission of the disease.…”

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confidence: 99%

“…5 Direct immunofluorescence, which shows IgG and C3 deposits in the epidermis, and indirect immunofluorescence, which detects antibodies directed against intercellular substances, allow differentiation between these two entities. 5 Treatment with oral steroids alone does not always lead to remission of the disease. Immunosuppressive drugs and dapsone may be associated with good therapeutic response, as in our patient's case.…”

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confidence: 99%

Pemphigus vegetans‐Neumann variant of the vulva

et al. 2023

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Pemphigus vegetans-Neumann variant of the vulva Dear Editor,A 65-year-old female patient presented with pruritic bullous and vesicular lesions of the vulva developing 4 months prior to her consultation without any evidence of asthenia or weight loss. On admission, the physical examination revealed an erosive vegetative lesion covering the vulvar region, the inguinal folds, the inner surfaces of the upper thighs, and the perianal region (Figure 1a,b). Additional examination conducted after admission revealed a labial erosion (Figure 1c). A skin

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Treatment of Pyodermatitis-Pyostomatitis Vegetans: A Systematic Review and Meta-analysis

Hobbs¹,

Zufall

Khalil

et al. 2021

J of Skin

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Background: Pyodermatitis-pyostomatitis vegetans (PDV-PSV) is a rare muco-cutaneous disorder characterized by vegetating and pustular plaques and is often associated with inflammatory bowel disease (IBD). The purpose of this study was to systematically identify and analyze reports of PDV-PSV to determine the most effective treatment. Methods: Reports of PDV-PSV were identified using the OVID-Medline database from inception through November 2019. Publications were excluded if no new patient case was included, if there was not clinical and histological evidence of PDV, PSV, or PDV-PSV, or if no treatment was discussed. Results: The final sample was comprised of 74 publications plus an additional patient from the authors’ institution, corresponding to 95 total patients. The basis of the review and analysis is limited to case reports and case series, which likely only report the cases with positive outcomes. Statistical analysis revealed that oral corticosteroids (OCS), 6-mercaptopurine/azathioprine, oral calcineurin inhibitors (OCNI), 5-aminosalicylic-acid (5-ASA), and biologics (BIO) were the most effective treatments for PDV-PSV. Topical medications, colchicine, oral dapsone, and other antibiotics were ineffective treatments, with topical medications being the least effective option. When OCS are used, they work best when used as initial treatment to induce remission. 5-ASA and BIO are most effective when used as maintenance therapies after initial remission. Conclusions: Thus, first line therapy for PDV-PSV should begin with OCS with transition to steroid-sparing agents including OCNI, BIO, and 5-ASA if indicated.

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Pyodermatitis-pyostomatitis vegetans

Cited by 3 publications

References 3 publications

Dermatological Manifestations in Inflammatory Bowel Diseases

Dermatological Manifestations in Inflammatory Bowel Diseases

Pemphigus vegetans‐Neumann variant of the vulva

Treatment of Pyodermatitis-Pyostomatitis Vegetans: A Systematic Review and Meta-analysis

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