Pyoderma vegetans and ulcerative colitis

Bianchi, Luca; Carrozzo, Anna Maria; Orlandi, Augusto; Campione, Elena; Hagman, J.; Chimenti, Sergio

doi:10.1046/j.1365-2133.2001.04237.x

Cited by 24 publications

(20 citation statements)

References 20 publications

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“…The differential diagnosis of PV should include pemphigus vegetans and deep fungal infections. Tuberculosis cutis verrucosa, pyoderma gangrenosum, halogenoderma, squamous cell carcinoma and Sweet syndrome must also be ruled out [1, 2, 3]. To differentiate PV from other diseases, evaluations of wound, yeast and mycobacterium tuberculosis culture and direct immunofluorescence study must be performed in order to rule out pemphigus vegetans.…”

Section: Discussionmentioning

confidence: 99%

“…To differentiate PV from other diseases, evaluations of wound, yeast and mycobacterium tuberculosis culture and direct immunofluorescence study must be performed in order to rule out pemphigus vegetans. The association of PV with UC is well known but rarely reported in literature [2, 3, 6, 8, 9, 10]. Since PV is considered a marker of inflammatory bowel disease, a presumptive diagnosis of PV should induce a complete gastrointestinal investigation.…”

Section: Discussionmentioning

confidence: 99%

“…PV often affects middle-aged men, is frequently associated with ulcerative colitis (UC) and is often difficult to treat [2]. Other diseases that might be linked to this condition include cutaneous T-cell lymphoma, primary immunodeficiencies, chronic myeloid leukemia, alcoholism, HIV infection and nutritional deficit [2, 3, 4]. Predisposing factors include microbial infections, halogen ingestion, foreign materials and tattoos in patients with a compromised immune system [3].…”

Section: Introductionmentioning

confidence: 99%

“…Other diseases that might be linked to this condition include cutaneous T-cell lymphoma, primary immunodeficiencies, chronic myeloid leukemia, alcoholism, HIV infection and nutritional deficit [2, 3, 4]. Predisposing factors include microbial infections, halogen ingestion, foreign materials and tattoos in patients with a compromised immune system [3]. However, it has also been reported in healthy patients [2, 5].…”

Section: Introductionmentioning

confidence: 99%

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Pyoderma Vegetans Associated with Ulcerative Colitis: A Case with Good Response to Steroids

Canpolat¹,

Cemil²,

Yılmazer

et al. 2011

Case Rep Dermatol

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Pyoderma vegetans (PV) is a very rare disorder characterized by erythematous, vesiculopustular, exudative, vegetating plaques usually localized in the inguinal and axillary folds. The etiology of PV is not known, but it is often associated with bacterial infections in immunocompromised patients. Major histopathological features in PV are pseudoepitheliomatous hyperplasia and intraepidermal and subepidermal neutrophilic or eosinophilic microabscesses. It is well known that these lesions are frequently associated with inflammatory bowel diseases, such as ulcerative colitis (UC) and Crohn’s disease. No standardized treatment plan is available for PV, although antibiotic treatment has often been used, with variable results. The standard first-line therapy is still systemic steroids. Herein, we report a case of PV associated with UC with unusual localization that showed a good response to systemic corticosteroid, antibiotic and sulfasalazine therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pyoderma Vegetans Associated with Ulcerative Colitis: A Case with Good Response to Steroids

Canpolat¹,

Cemil²,

Yılmazer

et al. 2011

Case Rep Dermatol

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“…HIV infection [10], malignant tumors, i.e. lymphomas [11], leukemia [12], carcinomas [13], alcoholism, nutritional deficit, diabetes mellitus [14], or therapy with immunosuppressive agents [4], and even in other situations such as bowel inflammatory disease [15, 16], and acne conglobata and follicular occlusion triad [17]. Treatment of this condition is usually very difficult.…”

Section: Discussionmentioning

confidence: 99%

Pyoderma Vegetans Associated with Severe Psoriatic Arthritis: Good Response to Etanercept

Carrera

Mascaró²,

Moreno-Romero³

et al. 2006

Dermatology

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Pyoderma vegetans (PV) is an inflammatory dermatosis, characterized clinically by large exudative vegetating plaques, and histopathologically by epidermal pseudoepitheliomatous hyperplasia and dense inflammatory infiltrates. Although PV is a very rare condition, it is a chronic disorder that may accompany any systemic process that compromises immunity. Treatment is very difficult, and correction of predisposing causes may be useful. We present a 49-year-old woman affected by severe psoriatic arthritis since she was 19, with giant verrucous plaques on her lower limbs that had worsened progressively during the last 15 years. After ruling out other vegetating cutaneous disorders, PV was diagnosed in association with psoriasis. Despite numerous previous systemic and topical therapeutic attempts no response was observed. Etanercept was introduced, which resulted in a marked improvement within 3 weeks. Herein, we report a diagnostic and therapeutic challenge of the first case of PV associated with psoriasis that presented a good response to etanercept.

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