Pyoderma gangrenosum with myelofibrosis

Kanel, Keith T.; Kroboth, Frank J.; Swartz, William M.

doi:10.1016/0002-9343(87)90170-7

Cited by 17 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The often break down rapidly. The overlap with lesions of Sweet's syndrome and the frequent associations with myeloproliferative disease 14,67–87 suggest a common pathogenetic basis 58,79 . Different forms of neutrophilic dermatosis, ranging from granuloma faciale through Sweet's syndrome to PG, can be seen in any given patient with myelodysplasia 86 .…”

Section: Clinical Featuresmentioning

confidence: 99%

Pyoderma gangrenosum: a review

2003

View full text Add to dashboard Cite

Since its first description in 1930, the pathogenesis of pyoderma gangrenosum (PG) has remained obscure even as an ever-widening array of systemic diseases has been described in association with it. The histopathologic distinction of PG from other ulcerative processes with dermal neutrophilia is challenging and at times impossible. In consequence, when confronted with a biopsy from such a lesion, the pathologist has an obligation to obtain a full and detailed clinical history. In short, as a diagnosis of PG does not hinge exclusively upon the biopsy findings in isolation from other studies, a solid knowledge of the clinical features, the systemic disease associations and the differential diagnosis will help the pathologist to avoid diagnostic pitfalls or the generation of a report which is non-contributory to patient care. In this review, we describe in detail the different clinicopathologic forms of PG, summarize the diseases associated with this process in the literature and in our experience, and briefly review the treatment options.

show abstract

Section: Clinical Featuresmentioning

confidence: 99%

Pyoderma gangrenosum: a review

2003

View full text Add to dashboard Cite

show abstract

“…, 2004). Case reports of its association with other haematological conditions such as autoimmune haemolysis, paroxysmal nocturnal haemoglobinuria, antiphospholipid syndrome and myelofibrosis are also documented (Kanel, Kroboth & Swartz, 1987; Goulden, Bond & Highet, 1994; Chacek et al. , 1998; Schmid et al.…”

Section: Introductionmentioning

confidence: 99%

Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone

2005

View full text Add to dashboard Cite

The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.

show abstract

“…In the literature review presented, a prominent rate of gastrointestinal (38.9%) and hematologic abnormalities (44.4%) was evident. References (all studies reported one patient with hand and finger involvement, except for Huish et al, 5 which reported a series of seven patients): Lucchina et al, 20 Reich et al, 21 Ghosn et al, 12 Zivanovic et al, 10 Mujadzic et al, 22 Weenig et al, 23 Greidanus and Honl, 7 Grange et al, 14 Youker et al, 9 Braun-Falco et al, 24 Manthey and Schissel, 5 Bennett et al, 4,6 Nurre et al, 26 Worley et al, 27 Adam et al, 28 Kitagawa et al, 29 Laurencin and Shoen, 30 Nihei et al, 31 Brown et al, 13 Gasparini et al, 32 Papilion and Bergfield, 33 Young et al, 34 Kanel et al, 35 Schwarz et al, 36 Griffiths and Sundaram, 37 Yusef and Ead, 38 By the time patients present for care of their lesions and analgesics, the red plaques and pustules have already rapidly evolved. On examination, an ulcer with necrosis of a mucopurulent base can be seen with violaceous raised borders.…”

Section: Discussionmentioning

confidence: 99%