Pyoderma Gangrenosum with Chronic Myeloid Leukaemia

Goldin, David

doi:10.1177/003591577406712p120

Cited by 14 publications

(3 citation statements)

References 2 publications

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“…Many kinds of clinical disorders have been associated with pyodertna gangrenosum, as shown in Table 4 and other reports (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The association of inflammatory bowel dis-ease with pyoderma gangrenosum has long been reeognized (28.…”

Section: Discussionmentioning

confidence: 87%

Histopathologic and immunopathologic study of pyoderma gangrenosum

et al. 1986

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Sixty-three patients with pyoderma gangrenosum were seen and studied at the Mayo Clinic from 1971 to 1980. Biopsies from the erythematous border or necrotic edge of the pyoderma gangrenosum lesions usually demonstrated a characteristic pathogenic morphologic evolution. The early lesions revealed mild to moderate perivascular lymphocytic infiltrate associated with endothelial swelling. The fully developed lesions demonstrated necrosis in addition to a dense lymphocytic infiltration surrounding as well as involving the blood vessels. Extravasation of erythrocytes and thrombosis sometimes were seen. Ulceration, infarction, and abscess formation were found in the later stages of evolution. Direct immunofluorescence results were positive in the blood vessels of 36 of 65 (55%) specimens. IgM, C3, and fibrin were found in the papillary and reticular dermal vessels. IgG and IgA were only occasionally present. Pyoderma gangrenosum appears to be a reactive process that is manifested as a vasculitis. Biopsy material from the advancing active erythematous border has early characteristic dermatopathologic findings of lymphocytic vasculitis. Cutaneous vascular immune deposits suggest an immune pathogenesis of either an immune complex disease or lymphocytotoxic reaction.

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Section: Discussionmentioning

confidence: 87%

Histopathologic and immunopathologic study of pyoderma gangrenosum

et al. 1986

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“…The often break down rapidly. The overlap with lesions of Sweet's syndrome and the frequent associations with myeloproliferative disease 14,67–87 suggest a common pathogenetic basis 58,79 . Different forms of neutrophilic dermatosis, ranging from granuloma faciale through Sweet's syndrome to PG, can be seen in any given patient with myelodysplasia 86 .…”

Section: Clinical Featuresmentioning

confidence: 99%

Pyoderma gangrenosum: a review

2003

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Since its first description in 1930, the pathogenesis of pyoderma gangrenosum (PG) has remained obscure even as an ever-widening array of systemic diseases has been described in association with it. The histopathologic distinction of PG from other ulcerative processes with dermal neutrophilia is challenging and at times impossible. In consequence, when confronted with a biopsy from such a lesion, the pathologist has an obligation to obtain a full and detailed clinical history. In short, as a diagnosis of PG does not hinge exclusively upon the biopsy findings in isolation from other studies, a solid knowledge of the clinical features, the systemic disease associations and the differential diagnosis will help the pathologist to avoid diagnostic pitfalls or the generation of a report which is non-contributory to patient care. In this review, we describe in detail the different clinicopathologic forms of PG, summarize the diseases associated with this process in the literature and in our experience, and briefly review the treatment options.

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“…In the literature the following diseases have been reported in concurrence with persistent cutaneous ulcers: regional enteritis, systemic lupus erythematosus, leukemia,, myelofibrosis, arthritis, chronic active hepatitis, chronic intravenous coagulopathy, hypoplastic anemia with tabes dorsalis, carcinoid syndrome, diabetes mellitus,, and rheumatoid arthritis together with diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Postsurgical, Chronic, Nonprogressive, Cutaneous Ulcers: A Possible Variant of Pyoderma Gangrenosum Associated with Diabetes Mellitus

Lim

Bart

1978

The Journal of Dermatologic Surgery and Oncology

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Two patients developed persistent ulcers on the trunk after cutaneous surgery. Both had "chemical" diabetes mellitus. Bacteriologic and histopathologic studies of the ulcers were not revealing of cause. The characteristics of the ulcers are described, and are contrasted with typical lesions of pyoderma gangrenosum and Meleney's postoperative progressive synergistic bacterial gangrene. We believe these patients had variant lesions of pyoderma gangrenosum.

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Pyoderma Gangrenosum with Chronic Myeloid Leukaemia

Cited by 14 publications

References 2 publications

Histopathologic and immunopathologic study of pyoderma gangrenosum

Histopathologic and immunopathologic study of pyoderma gangrenosum

Pyoderma gangrenosum: a review

Postsurgical, Chronic, Nonprogressive, Cutaneous Ulcers: A Possible Variant of Pyoderma Gangrenosum Associated with Diabetes Mellitus

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